{
  "abstract": "Drug repurposing has led to the identification of tamoxifen, a well-known chemotherapy drug, as a compound with relevant antibacterial properties. In this field, the development of new tamoxifen derivatives with antimicrobial activity, particularly against colistin-resistant Acinetobacter baumannii, represents an important area of research. We evaluated the MICs of 22 and 3 tamoxifen derivatives against wild-type and colistin-resistant A. baumannii strains, respectively, using microdilution assays, either as monotherapy or in combination with colistin. While all derivatives showed MIC values above 64 mg/L when tested as monotherapy, combining derivatives 1, 14, and 18 with colistin reduced tamoxifen derivatives’ MICs to 0.125–2 mg/L for the reference strain ATCC 17978 and to 0.5–1 mg/L for the colistin-resistant Ab22 strain. Growth assays showed that these derivatives delayed Ab22 proliferation during the first 4 h. Moreover, these derivatives increased membrane permeabilization without altering the expression of the outer membrane proteins (OMPs). These findings suggest that tamoxifen derivatives in combination with colistin exhibit antibacterial activity against a colistin-resistant A. baumannii, potentially broadening the spectrum of available drug treatments for combating MDR A. baumannii.",
  "abstract_shown": true,
  "affiliations": [
    "Universidad Pablo de Olavide/Consejo Superior de Investigaciones Científicas/Junta de Andalucía , , ,",
    "Università degli Studi di Milano , , Via Golgi 19 , ,",
    "University of Milan , , Via Celoria 2 , ,",
    "Universidad Pablo de Olavide , , ,"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Irene Molina Panadero"
    },
    {
      "affs": [
        0
      ],
      "name": "Angela Rey Hidalgo"
    },
    {
      "affs": [
        1
      ],
      "name": "Isabella Rimoldi",
      "orcid": "0000-0002-6210-0264"
    },
    {
      "affs": [
        1
      ],
      "name": "Giorgio Facchetti",
      "orcid": "0000-0002-1260-1335"
    },
    {
      "affs": [
        2
      ],
      "name": "Michael S. Christodoulou",
      "orcid": "0000-0002-5098-3143"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Younes Smani"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2swkm7d5xxq7v.bib",
  "cited_by": 0,
  "doi": "10.1021/acsomega.6c05050",
  "fulltext_url": "https://europepmc.org/articles/PMC13688546",
  "id": "2swkm7d5xxq7v",
  "issns": [
    "2470-1343"
  ],
  "landing_url": "https://pubs.acs.org/acsodf/article/11/41/62936/5446583/Use-of-Tamoxifen-Derivatives-in-Combination-with",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1313|Antibiotic Resistance in Bacteria"
    ]
  ],
  "openalex": "W7220836027",
  "pdf_url": "https://pubs.acs.org/doi/pdf/10.1021/acsomega.6c05050",
  "pmcid": "PMC13688546",
  "pmid": "42923980",
  "published": "2026-10-07",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/2swkm7d5xxq7v.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:39Z",
      "native_id": "10.1021/acsomega.6c05050",
      "source": "crossref",
      "url": "https://pubs.acs.org/acsodf/article/11/41/62936/5446583/Use-of-Tamoxifen-Derivatives-in-Combination-with"
    },
    {
      "first_seen": "2026-10-30T12:20:36Z",
      "native_id": "MED:42923980",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42923980"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1313|Antibiotic Resistance in Bacteria",
      "subfield": "general"
    }
  ],
  "title": "Use of Tamoxifen Derivatives in Combination with Colistin against Colistin-Resistant Acinetobacter baumannii",
  "title_text": "Use of Tamoxifen Derivatives in Combination with Colistin against Colistin-Resistant Acinetobacter baumannii",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:36Z",
  "url": "https://research.draconitic.com/paper/2swkm7d5xxq7v",
  "venue": "ACS Omega",
  "versions": []
}