{
  "abstract": "Isothermal titration calorimetry (ITC) combined with neutron diffraction and isotopic substitution (NDIS) has been used to elucidate the molecular origins of lower critical solution temperature (LCST) behaviour in the tetrabutylphosphonium 5-phenyltetrazolate/water ([P4444][Ph−tet]/H2O) system. Comparison with the structurally similar but fully water-miscible analogue, tetrabutylphosphonium benzoate ([P4444][Bz]) reveals a much smaller negative enthalpy of mixing with water. This is indicative that weaker solvation of the [Ph−tet]–anion drives an entropy-dominated desolvation process upon heating, leading to phase separation into IL-rich and water-rich domains and is supported by observation from NDIS that the [Ph−tet]–anion is only weakly hydrated by water.",
  "abstract_shown": true,
  "affiliations": [
    "School of Chemistry and Chemical Engineering, Queen’s University Belfast, David Keir Building, Stranmillis Road, Belfast, UK, BT9 5AG",
    "ENS Lyon, CNRS and Université de Lyon, 46 allée d’Italie, Lyon, France, 69364",
    "Rutherford Appleton Laboratory",
    "Harwell Science & Innovation Campus"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Sanskrita Madhukailya",
      "orcid": "0009-0009-3052-5792"
    },
    {
      "affs": [
        1
      ],
      "name": "Guillaume Depraetère"
    },
    {
      "affs": [
        1
      ],
      "name": "Nithavong Cam"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Tristan G. A. Youngs"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "James P. Tellam"
    },
    {
      "affs": [
        1
      ],
      "name": "Margarida Costa Gomes"
    },
    {
      "affs": [
        0
      ],
      "name": "Leila Moura"
    },
    {
      "affs": [
        0
      ],
      "name": "John D. Holbrey"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2txpwx01gqhk9.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15008428/v1",
  "fulltext_url": null,
  "id": "2txpwx01gqhk9",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15008428/v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1503|Ionic liquids properties and applications"
    ]
  ],
  "openalex": "W7211900374",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-07",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/2txpwx01gqhk9.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:17Z",
      "native_id": "10.26434/chemrxiv.15008428",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15008428/v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1503|Ionic liquids properties and applications",
      "subfield": "catalysis"
    }
  ],
  "title": "Weak Anion Hydration Drives LCST Behaviour in Ionic Liquid–Water Mixtures: Insights from Calorimetry and Neutron Diffraction",
  "title_text": "Weak Anion Hydration Drives LCST Behaviour in Ionic Liquid–Water Mixtures: Insights from Calorimetry and Neutron Diffraction",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:17Z",
  "url": "https://research.draconitic.com/paper/2txpwx01gqhk9",
  "venue": "ChemRxiv",
  "versions": []
}