{
  "abstract": "Pediatric evidence for therapeutic plasma exchange (TPE) is largely small, single-center cohorts; there is no prior large-scale age-stratified outcomes assessment. Using the TriNetX US Collaborative Network, we identified 3744 patients ≤ 17 years old undergoing an index TPE procedure, stratified into four age groups (≤ 1, 2-5, 6-12, and 13-17 years). ICD-10-CM diagnosis codes recorded 30 days prior to the index procedure were mapped to American Society for Apheresis Categories I-III indications; three high-prevalence nonspecific codes were tracked separately. All-cause mortality at 30 days, 90 days, and 1 year was assessed. All-cause mortality decreased with increasing age at every time window: 30-day mortality ranged from 16.8% (≤ 1 year) to 4.3% (13-17 years, p < 0.0001). Infant mortality risk was concentrated disproportionately in the first 90 days postprocedure. Sex distribution shifted from a slight male predominance in infancy and early childhood (55%-56% male) to a female predominance in adolescence (55% female, p < 0.0001). Leading specific indications were autoimmune encephalitis (10%), sepsis with multiorgan failure (9%), renal transplant rejection (6%), acute disseminated encephalomyelitis (5%), Guillain-Barré syndrome (5%), and myasthenia gravis (4%); nonspecific diagnosis codes were each individually more prevalent than any single ASFA-mapped indication. This is the first large-scale, age-stratified, multi-institutional characterization of pediatric TPE. We identified an inverse relationship between age and all-cause mortality, a sex-distribution shift in adolescence, and an indication landscape dominated by nonspecific diagnosis codes. These findings offer age-stratified benchmarks for clinical counseling and hypothesis generation.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 1,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Caitlin Raymond",
      "orcid": "0000-0001-5474-1996"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2v3g8wh6q8rbb.bib",
  "cited_by": 0,
  "doi": "10.1002/jca.70198",
  "fulltext_url": "https://europepmc.org/articles/PMC13680636",
  "id": "2v3g8wh6q8rbb",
  "issns": [
    "0733-2459",
    "1098-1101"
  ],
  "landing_url": "https://europepmc.org/article/MED/42897738",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2704|Blood transfusion and management"
    ]
  ],
  "openalex": "W7223055884",
  "pdf_url": "https://europepmc.org/articles/PMC13680636?pdf=render",
  "pmcid": "PMC13680636",
  "pmid": "42897738",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/2v3g8wh6q8rbb.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:37Z",
      "native_id": "MED:42897738",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42897738"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2704|Blood transfusion and management",
      "subfield": "general"
    }
  ],
  "title": "Therapeutic Plasma Exchange in Pediatric Patients: A Multi-Institutional Landscape Analysis.",
  "title_text": "Therapeutic Plasma Exchange in Pediatric Patients: A Multi-Institutional Landscape Analysis.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:37Z",
  "url": "https://research.draconitic.com/paper/2v3g8wh6q8rbb",
  "venue": "Journal of clinical apheresis",
  "versions": []
}