{
  "abstract": "Background: Decellularized aortic homografts were developed to reduce immunogenicity, but very long-term outcomes remain incompletely characterized.\n\nCase Summary: A 54-year-old woman underwent aortic root replacement with a 22-mm SynerGraft decellularized homograft for bicuspid aortic valve disease and aortic root aneurysm. Nineteen years later, she presented with acute heart failure caused by severe aortic insufficiency. Preoperative imaging demonstrated a heavily calcified retrosternal aortic root, guiding a bilateral thoracosternotomy for redo root replacement. Operative and histopathologic findings showed extensive calcific degeneration with left coronary leaflet disruption. Recovery was uneventful.\n\nDiscussion: This case illustrates a possible very late failure pattern of a decellularized homograft and underscores the importance of meticulous preoperative imaging and individualized operative planning.\n\nTake-Home Messages: Decellularized aortic homografts may remain susceptible to very late structural degeneration. Careful imaging and tailored surgical planning are essential for complex redo aortic root surgery.",
  "abstract_shown": true,
  "affiliations": [
    "School of Medicine, University of Patras School of Medicine, Patras, Greece",
    "Division of Cardiac Surgery, The Johns Hopkins Hospital, Baltimore, Maryland, USA",
    "Georgetown University School of Medicine, Washington DC, USA",
    "School of Medicine, Koc University School of Medicine, Istanbul, Turkey"
  ],
  "article_type": "case report",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Fotios Kalafatakis"
    },
    {
      "affs": [
        1
      ],
      "name": "Uzma Rahman"
    },
    {
      "affs": [
        2
      ],
      "name": "Sriharsha Talapaneni"
    },
    {
      "affs": [
        3
      ],
      "name": "Hazar Kadirogullari"
    },
    {
      "affs": [
        1
      ],
      "name": "Ahmet Kilic"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2veknpp58bb1v.bib",
  "cited_by": 1,
  "doi": "10.1016/j.jaccas.2026.109897",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13698934/",
  "id": "2veknpp58bb1v",
  "issns": [
    "2666-0849"
  ],
  "landing_url": "https://doi.org/10.1016/j.jaccas.2026.109897",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Clinical Case"
    ],
    [
      "heading",
      "Valvular Heart Disease"
    ],
    [
      "lcc",
      "RC666-701"
    ],
    [
      "openalex",
      "2740|Aortic Disease and Treatment Approaches"
    ]
  ],
  "openalex": "W7206150852",
  "pdf_url": null,
  "pmcid": "PMC13698934",
  "pmid": "42684229",
  "published": "2026-09-02",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/2veknpp58bb1v.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:38Z",
      "native_id": "PMC13698934",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.jaccas.2026.109897"
    },
    {
      "first_seen": "2026-10-30T13:43:16Z",
      "native_id": "d99f271a03ca457d91d4fd682191a6f0",
      "source": "doaj",
      "url": "https://doi.org/10.1016/j.jaccas.2026.109897"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:RC666-701",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Late Failure of Decellularized Cryopreserved Aortic Homograft",
  "title_text": "Late Failure of Decellularized Cryopreserved Aortic Homograft",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:43:16Z",
  "url": "https://research.draconitic.com/paper/2veknpp58bb1v",
  "venue": "JACC Case Reports",
  "versions": []
}