{
  "abstract": "The high cost of growth factors has limited the commercial-scale production of cultivated meat products. In this study, we report on the synthesis and characterization of a series of naringin phenolate salts. Phenolate salts with sodium (Na+), potassium (K+), calcium (Ca2+), and tetrabutylammonium (TBA+) counterions were prepared to introduce water solubility to the natural flavonoid naringin. The synthesized salts were comprehensively characterized to confirm their chemical structures. Solvated cations were examined for their effect on the salts' physicochemical and biological properties. Solubility studies show that alkali metal salts are highly soluble in water, while the Ca2+ and TBA+ salts are less soluble. Acid regeneration studies confirm the reversibility of the salt formation. Preliminary studies indicate that selected naringin salts may support cell proliferation in cultivated meat systems. Overall, this study presents the first comprehensive report on naringin phenolate salts and their potential use in cultivated meat production.",
  "abstract_shown": true,
  "affiliations": [
    "Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem91120, Israel.",
    "SuperMeat Co., The Essence of Meat Ltd, Pinhas Sapir 3, Nes Ziona7403626, Israel.",
    "Department of Translational Science and Medicine, College of Community Health Sciences and the Center for Convergent Bioscience and Medicine (CCBM), The University of Alabama, Tuscaloosa, Alabama35401, United States."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Matilda Dirawy"
    },
    {
      "affs": [
        0
      ],
      "name": "Muhammad Abdel-Haq",
      "orcid": "0009-0002-6882-9774"
    },
    {
      "affs": [
        1
      ],
      "name": "Sarah E Hasenson"
    },
    {
      "affs": [
        0
      ],
      "name": "Sara Mahajna"
    },
    {
      "affs": [
        0
      ],
      "name": "Mohamed Mahameed"
    },
    {
      "affs": [
        2
      ],
      "name": "M N V Ravi Kumar",
      "orcid": "0000-0001-5606-401X"
    },
    {
      "affs": [
        2
      ],
      "name": "Meenakshi Arora",
      "orcid": "0000-0003-3809-3153"
    },
    {
      "affs": [
        0
      ],
      "name": "Abraham J Domb",
      "orcid": "0000-0002-2241-7726"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2vfjtcnphbv18.bib",
  "cited_by": 0,
  "doi": "10.1021/acs.jafc.6c09167",
  "fulltext_url": "https://europepmc.org/articles/PMC13651613",
  "id": "2vfjtcnphbv18",
  "issns": [
    "0021-8561",
    "1520-5118"
  ],
  "landing_url": "https://europepmc.org/article/MED/42915796",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2704|Phytochemicals and Antioxidant Activities"
    ]
  ],
  "openalex": "W7214226187",
  "pdf_url": "https://europepmc.org/articles/PMC13651613?pdf=render",
  "pmcid": "PMC13651613",
  "pmid": "42915796",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/2vfjtcnphbv18.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:36Z",
      "native_id": "MED:42915796",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42915796"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2704|Phytochemicals and Antioxidant Activities",
      "subfield": "general"
    }
  ],
  "title": "Synthesis and Characterization of Naringin Phenolate Salts for Cultivated Meat.",
  "title_text": "Synthesis and Characterization of Naringin Phenolate Salts for Cultivated Meat.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:36Z",
  "url": "https://research.draconitic.com/paper/2vfjtcnphbv18",
  "venue": "Journal of agricultural and food chemistry",
  "versions": []
}