{
  "abstract": "We report a fatal case of presumed primary hepatic epithelioid angiosarcoma (PHEA) in an 82-year-old woman with back pain, abdominal distension, and hyponatremia. Imaging showed ascites and hypodense hepatic lesions. Ascitic cytology was negative. Liver biopsy showed malignant cells with positive erythroblast transformation-specific regulated gene 1 (ERG) and cluster of differentiation 31 (CD31) on immunohistochemistry. Patchy synaptophysin and caudal-type homeobox 2 positivity initially suggested a neuroendocrine tumor but proved aberrant; negative chromogranin with ERG/CD31 positivity supported PHEA. She was transitioned to hospice care due to rapid clinical decline. This case highlights the atypical presentation, diagnostic pitfalls, and aggressive clinical course of PHEA.",
  "abstract_shown": true,
  "affiliations": [
    "Mercy Hospital, Fort Smith, AR",
    "Arkansas College of Osteopathic Medicine, Fort Smith, AR",
    "Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan",
    "King Edward Medical University, Lahore, Pakistan",
    "Allama Iqbal Medical College, Lahore, Pakistan"
  ],
  "article_type": "case report",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Muhammad Usman",
      "orcid": "0000-0001-7689-9479"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Muhammad Usman Shahbaz"
    },
    {
      "affs": [
        2
      ],
      "name": "Arsalan Ahmed"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Muahammad Zawar Asif"
    },
    {
      "affs": [
        2
      ],
      "name": "Adnan Memon"
    },
    {
      "affs": [
        3
      ],
      "name": "Laiba Murtaza"
    },
    {
      "affs": [
        4
      ],
      "name": "Rafif Ahmed"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2vr09bbzq49c2.bib",
  "cited_by": 0,
  "doi": "10.14309/crj.0000000000002389",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13734565/",
  "id": "2vr09bbzq49c2",
  "issns": [
    "2326-3253"
  ],
  "landing_url": "https://doi.org/10.14309/crj.0000000000002389",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Case Report"
    ],
    [
      "heading",
      "Liver"
    ],
    [
      "openalex",
      "2730|Vascular Tumors and Angiosarcomas"
    ]
  ],
  "openalex": "W7225240378",
  "pdf_url": null,
  "pmcid": "PMC13734565",
  "pmid": "42985268",
  "published": "2026-11-04",
  "publisher": "American College of Gastroenterology",
  "ris": "https://research.draconitic.com/paper/2vr09bbzq49c2.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:24:01Z",
      "native_id": "PMC13734565",
      "source": "pmc",
      "url": "https://doi.org/10.14309/crj.0000000000002389"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Vascular Tumors and Angiosarcomas",
      "subfield": "oncology"
    }
  ],
  "title": "Hepatic Epithelioid Angiosarcoma with Abberrant Synaptophysin and CDX2 Expression Mimicking Neuroendocrine/Metastatic Carcinoma: A Fatal Case Report",
  "title_text": "Hepatic Epithelioid Angiosarcoma with Abberrant Synaptophysin and CDX2 Expression Mimicking Neuroendocrine/Metastatic Carcinoma: A Fatal Case Report",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:24:01Z",
  "url": "https://research.draconitic.com/paper/2vr09bbzq49c2",
  "venue": "ACG Case Reports Journal",
  "versions": []
}