{
  "abstract": "In a recent paper published in Cancer Cell, we identified subclinical cholestasis as an accessible imprint of gut dysbiosis predicting resistance to immune checkpoint blockade. Our work connects γ-glutamyl transferase, bile-acid remodeling, and MAdCAM-1 loss to compromised antitumor immunity, opening avenues for novel biomarker-guided microbiota interventions.",
  "abstract_shown": true,
  "affiliations": [
    "Gustave Roussy (GRCC), ClinicObiome, Inserm UMR1367, Microbiota and Mucosal Immunity for Cancer Immunotherapy, Université Paris-Saclay, Villejuif, France.",
    "Centre de Recherche des Cordeliers, INSERM U1138, Équipe Labellisée - Ligue Nationale Contre le Cancer, Université Paris Cité, Sorbonne Université, Paris, France.",
    "INSERM US23, Analyse moléculaire, modélisation et imagerie de la maladie Cancéreuse, Plateformes de Métabolomique et de Criblage Cellulaire Haut Débit, Université Paris-Saclay, Villejuif, France.",
    "Institut Du Cancer Paris CARPEM, Department of Biology, Hôpital Européen Georges Pompidou, AP-HP, Paris, France."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Anne-Laure Mallard de La Varende",
      "orcid": "0009-0009-2724-4498"
    },
    {
      "affs": [
        0
      ],
      "name": "Marine Fidelle",
      "orcid": "0000-0002-5589-9688"
    },
    {
      "affs": [
        1,
        2,
        3
      ],
      "name": "Guido Kroemer",
      "orcid": "0000-0002-9334-4405"
    },
    {
      "affs": [
        0
      ],
      "name": "Laurence Zitvogel"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2w4ssxy83mpxb.bib",
  "cited_by": 0,
  "doi": "10.1080/2162402x.2026.2748140",
  "fulltext_url": "https://europepmc.org/articles/PMC13679315",
  "id": "2w4ssxy83mpxb",
  "issns": [
    "2162-4011",
    "2162-402X"
  ],
  "landing_url": "https://europepmc.org/article/MED/42878219",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2730|Cancer Immunotherapy and Biomarkers"
    ]
  ],
  "openalex": "W7222207997",
  "pdf_url": "https://europepmc.org/articles/PMC13679315?pdf=render",
  "pmcid": "PMC13679315",
  "pmid": "42878219",
  "published": "2026-10-15",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/2w4ssxy83mpxb.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:46Z",
      "native_id": "MED:42878219",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42878219"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Cancer Immunotherapy and Biomarkers",
      "subfield": "oncology"
    }
  ],
  "title": "Biomarkers of subclinical cholestasis predict cancer immunotherapy outcomes.",
  "title_text": "Biomarkers of subclinical cholestasis predict cancer immunotherapy outcomes.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:46Z",
  "url": "https://research.draconitic.com/paper/2w4ssxy83mpxb",
  "venue": "Oncoimmunology",
  "versions": []
}