{
  "abstract": "Background: Dimethyl fumarate (DMF) is approved as a first-line treatment in relapsing-remitting multiple sclerosis (RRMS).\n\nAim: To evaluate the demographic, clinical, and radiological outcomes of DMF treatment in a real-world setting.\n\nStudy design: Multicenter retrospective study based on data from 61 clinics across Türkiye.\n\nMethods: Side effects, leukocyte and lymphocyte counts, liver enzymes, EDSS (Expanded Disability Status Scale), and upper- and lower-extremity test results were evaluated in patients with RRMS before DMF initiation and at 1, 6, 12, and 24 months. Additionally, NEDA-3 (No Evidence of Disease Activity-3) status was assessed at the 1 and 2-year follow-ups.\n\nResults: 1,749 patients participated in this retrospective study. The most common side effects were flushing and gastrointestinal symptoms, which were more frequent in women and in patients with lower weight and lower Body Mass Index (BMI). Leukocyte and lymphocyte counts initially decreased and then stabilized, whereas transient elevations in liver enzymes resolved during follow-up. EDSS scores showed a significant improvement beginning at the 6-month follow-up. Performance on the Nine-Hole Peg Test (9HPT) improved, whereas no significant change was observed in the Timed 25-Foot Walk (T25FW). In addition, approximately 70% of the patients achieved NEDA-3 status at both the 1 and 2-year follow-ups.\n\nConclusion: DMF demonstrated a favorable safety profile and was associated with significant improvements in EDSS while maintaining NEDA-3 status in approximately 70% of patients with RRMS. Adverse events occurred more frequently among women and among patients with lower body weight and lower BMI.",
  "abstract_shown": true,
  "affiliations": [
    "Faculty of Medicine, Department of Neurology, Ondokuz Mayis University",
    "Faculty of Medicine, Department of Neurology, Katip Çelebi University",
    "Faculty of Medicine, Department of Neurology, Yeditepe University",
    "Faculty of Medicine, Department of Physiology, Ondokuz Mayis University",
    "Graduate Education Institute, Department of Neuroscience, Ondokuz Mayis University",
    "Faculty of Medicine, Department of Neurology, Erciyes University",
    "Haydarpaşa Research and Training Hospital, Neurology Clinic",
    "Başakşehir Çam Sakura City Hospital, Neurology Clinic, Başakşehir",
    "Faculty of Medicine, Department of Neurology, Bursa Uludağ University, Nilüfer",
    "Haseki Research and Training Hospital, Neurology Clinic",
    "Faculty of Medicine, Department of Neurology, Kocaeli University",
    "Faculty of Medicine, Department of Neurology, Hacettepe University",
    "Faculty of Medicine, Department of Neurology, Harran University",
    "Neurology Clinic, Bilkent City Hospital",
    "Faculty of Medicine, Department of Neurology, Firat University",
    "Faculty of Medicine, Department of Neurology, Atatürk University",
    "Neurology Clinic, Bursa Yuksek Ihtisas Research and Training Hospital",
    "Faculty of Medicine, Department of Neurology, Gaziantep University",
    "Faculty of Medicine, Department of Neurology, Sakarya University",
    "Faculty of Medicine, Department of Neurology, Marmara University",
    "Faculty of Medicine, Department of Neurology, Karadeniz Technical University",
    "Faculty of Medicine, Department of Neurology, Ege University",
    "Faculty of Medicine, Department of Neurology, Kahramanmaraş Sütçü Imam University",
    "Faculty of Medicine, Department of Neurology, Tekirdag Namik Kemal University",
    "Faculty of Medicine, Department of Neurology, Tokat Gaziosmanpaşa University",
    "Faculty of Medicine, Department of Neurology, Inönü University",
    "Neurology Clinic, Samsun City Hospital",
    "Neurology Clinic, Bozyaka Research and Training Hospital",
    "Neurology Clinic, Etlik City Hospital",
    "Faculty of Medicine, Department of Neurology Van Yüzüncüyil University",
    "Faculty of Medicine, Department of Neurology, Eskisehir Osmangazi University, Odunpazari",
    "Faculty of Medicine, Department of Neurology, Ahi Evran University",
    "Neurology Clinic, Süleyman Yalçin City Hospital, Kadiköy",
    "Neurology Clinic, Taksim Research and Training Hospital",
    "Neurology Clinic, Eskişehir City Hospital, Odunpazari",
    "Faculty of Medicine, Department of Neurology, Sivas Cumhuriyet University",
    "Faculty of Medicine, Department of Neurology, Süleyman Demirel University",
    "Neurology Clinic, Gülhane Research and Training Hospital",
    "Faculty of Medicine, Department of Neurology, Adiyaman University",
    "Faculty of Medicine, Department of Neurology, Bolu Abant Izzet Baysal University"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 103,
  "authors": [
    {
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        0
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      "name": "Sedat Şen"
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    {
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        1
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      "name": "Yeşim Beckmann"
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        2
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      "name": "Rana Karabudak"
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        3
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        4
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      "name": "Elif Merve Helvacı"
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        5
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      "name": "Mehmet Fatih Yetkin"
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        1
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      "name": "Cihat Uzunköprü"
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      "name": "Recai Türkoǧlu"
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      "name": "Saltanat Mert"
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      "name": "Aylin Akçali"
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      "name": "Kadriye Aǧan"
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      "name": "Nur Yüceyar"
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      "name": "Yılmaz İnanç"
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      "name": "Furkan Sarıdaş"
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      "name": "Nilda Turgut"
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      "name": "Ali Özhan Sivaci"
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      "name": "Dürdane Aksoy"
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      "name": "Ömer Faruk Turan"
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      "name": "Nazire Pınar Acar Özer"
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      "name": "Mehmet Tecellioǧlu"
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      "name": "Aysu Çetiner Şeker"
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      "name": "Gülin Sünter"
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      "name": "Asli Köşderelioǧlu"
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        28
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      "name": "Fatma Avşar Ertürk"
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        29
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      "name": "Vedat Çilingir"
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        30
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      "name": "Gülnur Tekgöl Uzuner"
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      "affs": [
        31
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      "name": "Aydan Köysüren"
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    {
      "affs": [
        28
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      "name": "Bülent Güven"
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    {
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        28
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      "name": "Huriye Hayat Güven"
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    {
      "affs": [
        32
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      "name": "Ilknur Aydin Cantürk"
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    {
      "affs": [
        33
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      "name": "Burcu Altunrende"
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        21
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      "name": "Bedriye Karaman"
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    {
      "affs": [
        34
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      "name": "Gülgün Uncu"
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    {
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        35
      ],
      "name": "Şeyda Figül Gökçe"
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    {
      "affs": [
        18
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      "name": "Dilcan Kotan"
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    {
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        23
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      "name": "Asli Aksoy Gündoǧdu"
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    {
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        36
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      "name": "Serpil Demirci"
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        37
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      "name": "Bilgin Öztürk"
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    {
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        38
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      "name": "Yaşar Altun"
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        39
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      "name": "Şule Aydin Türkoǧlu"
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    {
      "name": "Melike Batum"
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    {
      "name": "Zeynep Özdemir"
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        16
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      "name": "Azize Esra Gürsoy"
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    {
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        28
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      "name": "Duygu Arslan Mehdiyev"
    },
    {
      "name": "Rabia Gökçen Gözübatik Çelik"
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        28
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      "name": "Zeynep Özözen Ayas"
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  "bibtex": "https://research.draconitic.com/paper/2w81rer1wgr9b.bib",
  "cited_by": 0,
  "doi": "10.3389/fneur.2026.1920500",
  "fulltext_url": "https://www.frontiersin.org/articles/10.3389/fneur.2026.1920500/full",
  "id": "2w81rer1wgr9b",
  "issns": [
    "1664-2295"
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  "landing_url": "https://www.frontiersin.org/articles/10.3389/fneur.2026.1920500/full",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC346-429"
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  "published": "2026-11-03",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/2w81rer1wgr9b.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T12:21:35Z",
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  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:RC346-429",
      "subfield": "neurology"
    }
  ],
  "title": "Dimethyl fumarate in the treatment of multiple sclerosis: real-world effectiveness in a Turkish cohort",
  "title_text": "Dimethyl fumarate in the treatment of multiple sclerosis: real-world effectiveness in a Turkish cohort",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T14:20:21Z",
  "url": "https://research.draconitic.com/paper/2w81rer1wgr9b",
  "venue": "Frontiers in Neurology",
  "versions": []
}