{
  "abstract": "Quercetin (QUE) and resveratrol (RES) have complementary bioactivities but limited aqueous solubility and oral bioavailability. This study developed dual-loaded quercetin-resveratrol niosomes (QR-NIOs) for incorporation into hummus and screened quercetin:resveratrol molar ratios using antioxidant, erythroprotective, and enzyme-inhibition assays. The 50:50 formulation showed the broadest activity profile and produced vesicles with 90.63 ± 3.63% overall encapsulation efficiency, 149 ± 13 nm diameter, 0.21 ± 0.02 polydispersity index, and -34 ± 2 mV ζ-potential. After 24 h, dialysis passage was 51.63%, compared with 80.35% for the unencapsulated mixture. Following simulated intestinal digestion, enriched hummus yielded 5.8 milligrams of gallic acid equivalents per gram of dry weight (mg GAE/g D.W.) and 4.7 milligrams of quercetin equivalents per gram of dry weight (mg QE/g D.W.) in the dialyzable phenolic and flavonoid fractions, respectively, exceeding both controls while retaining antioxidant and enzyme-inhibitory activities. Over 28 days at 4 °C, microbial counts remained below detection limits and the tested pathogens were absent. Overall acceptability (8.23/9) did not differ significantly from commercial hummus. QR-NIO-enriched hummus represents a sensory-compatible functional-food prototype with sustained apparent release and increased intestinal recovery of assay-reactive phenolic and flavonoid compounds; compound-specific and in vivo validation remains necessary.",
  "abstract_shown": true,
  "affiliations": [
    "Departamento de Ciencias de la Salud, Centro Universitario de los Valles (CUValles), Universidad de Guadalajara, Carretera a Guadalajara Km 45.5, Ameca 46600, Jalisco, Mexico.",
    "Departamento de Ciencias Médicas y de la Vida, Centro Universitario de la Ciénega (CUCIÉNEGA), Universidad de Guadalajara, Av. Universidad 1115, Lindavista, Ocotlán 47820, Jalisco, Mexico.",
    "Departamento de Investigación y Posgrado en Alimentos (DIPA), Universidad de Sonora, Blvd. Luis Encinas y Rosales S/N, Col. Centro, Hermosillo 83000, Sonora, Mexico.",
    "Departamento de Ecología Aplicada, Centro Universitario de Ciencias Biológicas y Agropecuarias (CUCBA), Universidad de Guadalajara, Camino Ing. Ramón Padilla Sánchez No. 2100, Las Agujas, Zapopan 45510, Jalisco, Mexico."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jade Alejandra Miramontes-Piedra"
    },
    {
      "affs": [
        1
      ],
      "name": "Miguel Ángel Robles-García",
      "orcid": "0000-0002-6379-5088"
    },
    {
      "affs": [
        2
      ],
      "name": "Alejandra Vázquez-Aguilar"
    },
    {
      "affs": [
        0
      ],
      "name": "Brenda Vega-Ruiz",
      "orcid": "0000-0003-1005-3117"
    },
    {
      "affs": [
        2
      ],
      "name": "Carmen Lizette Del-Toro-Sánchez",
      "orcid": "0000-0001-7029-7741"
    },
    {
      "affs": [
        0
      ],
      "name": "Fridha Viridiana Villalpando-Vargas",
      "orcid": "0000-0003-0747-5087"
    },
    {
      "affs": [
        0
      ],
      "name": "Sergio Yair Rodríguez-Preciado",
      "orcid": "0000-0002-8612-2855"
    },
    {
      "affs": [
        0
      ],
      "name": "Mariana Díaz-Zaragoza",
      "orcid": "0000-0001-7427-5865"
    },
    {
      "affs": [
        0
      ],
      "name": "Juan Carlos Barrera-de-León"
    },
    {
      "affs": [
        3
      ],
      "name": "Ernesto Ramírez-Briones",
      "orcid": "0000-0002-1428-2542"
    },
    {
      "affs": [
        0
      ],
      "name": "Ricardo Iván González-Vega",
      "orcid": "0000-0002-4002-5902"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2wrrks4dmt5rz.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms27198686",
  "fulltext_url": "https://europepmc.org/articles/PMC13665077",
  "id": "2wrrks4dmt5rz",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://europepmc.org/article/MED/42883931",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1106|Microencapsulation and Drying Processes"
    ]
  ],
  "openalex": "W7214671542",
  "pdf_url": "https://europepmc.org/articles/PMC13665077?pdf=render",
  "pmcid": "PMC13665077",
  "pmid": "42883931",
  "published": "2026-09-28",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/2wrrks4dmt5rz.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:16Z",
      "native_id": "MED:42883931",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42883931"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "issn:1422-0067",
      "subfield": "general"
    }
  ],
  "title": "Dual-Loaded Quercetin-Resveratrol Niosomes: Sustained In Vitro Release and Retained Bioactivity in Hummus During Simulated Gastrointestinal Digestion.",
  "title_text": "Dual-Loaded Quercetin-Resveratrol Niosomes: Sustained In Vitro Release and Retained Bioactivity in Hummus During Simulated Gastrointestinal Digestion.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:16Z",
  "url": "https://research.draconitic.com/paper/2wrrks4dmt5rz",
  "venue": "International journal of molecular sciences",
  "versions": []
}