{
  "abstract": "Solute carrier (SLC) transporters play a central role in tumor metabolism by mediating the uptake of amino acids and sugars required for cancer cell growth and survival. Their proper function is crucial for maintaining cellular homeostasis, and their dysregulation contributes to metabolic reprogramming, tumor progression, and therapy resistance. Recent studies have identified non-coding RNAs (ncRNAs), including microRNAs, long non-coding RNAs, and circular RNAs, as key regulators of SLC transporter expression and function. This review provides a focused and comprehensive overview of the intricate regulatory networks between ncRNAs and amino acid and sugar transporters within the SLC family, highlighting their implications in cancer. We summarize current evidence on direct and indirect regulatory mechanisms, including transcriptional, post-transcriptional, and epigenetic pathways, and discuss how these interactions reshape cancer metabolism. We highlight existing knowledge gaps, such as context-dependent regulation, indirect regulatory networks, and limited mechanistic validation in vivo. Finally, we discuss the therapeutic potential and challenges of targeting ncRNA-SLC networks. A deeper understanding of these interactions may facilitate the development of novel therapeutic approaches aimed at improving cancer treatment outcomes.",
  "abstract_shown": true,
  "affiliations": [
    "Nephrology and Urology Research Center, Clinical Sciences Institute, Baqiyatallah University of Medical Sciences, Tehran, Islamic Republic of Iran. houshmandi.kia7@ut.ac.ir.",
    "Department of Pediatrics, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran.",
    "Department of Cell Systems and Anatomy, Long School of Medicine, UT Health San Antonio, San Antonio, TX, USA.",
    "Applied Microbiology Research Center, Biomedicine Technologies Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.",
    "Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital, TeMs.C., Islamic Azad University, Tehran, Iran.",
    "Guangzhou Key Laboratory of Digestive Diseases, Department of Gastroenterology and Hepatology, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, 510180, China.",
    "Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong.",
    "Department of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran. Shokoohmoghadam@yahoo.com.",
    "Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.",
    "Department of Gastroenterology, Department of Gastroenterology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China. 1402744723@smu.edu.cn.",
    "Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117600, Singapore. phcgs@nus.edu.sg."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Kiavash Hushmandi",
      "orcid": "0000-0001-5682-5392"
    },
    {
      "affs": [
        1
      ],
      "name": "Hassan Abolghasemi"
    },
    {
      "affs": [
        2
      ],
      "name": "Russel J Reiter"
    },
    {
      "affs": [
        3
      ],
      "name": "Abbas Ali Imani Fooladi"
    },
    {
      "affs": [
        4
      ],
      "name": "Najma Farahani"
    },
    {
      "affs": [
        5
      ],
      "name": "Liping Liang"
    },
    {
      "affs": [
        6
      ],
      "name": "William C Cho"
    },
    {
      "affs": [
        7
      ],
      "name": "Shokooh Salimimoghadam"
    },
    {
      "affs": [
        8
      ],
      "name": "Mina Alimohammadi"
    },
    {
      "affs": [
        9
      ],
      "name": "Le Liu"
    },
    {
      "affs": [
        10
      ],
      "name": "Gautam Sethi"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2wsjf65enhy5h.bib",
  "cited_by": 0,
  "doi": "10.1186/s12935-026-04431-y",
  "fulltext_url": "https://europepmc.org/articles/PMC13753109",
  "id": "2wsjf65enhy5h",
  "issns": [
    "1475-2867"
  ],
  "landing_url": "https://europepmc.org/article/MED/43009992",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1306|Cancer, Hypoxia, and Metabolism"
    ]
  ],
  "openalex": "W7203485152",
  "pdf_url": "https://europepmc.org/articles/PMC13753109?pdf=render",
  "pmcid": "PMC13753109",
  "pmid": "43009992",
  "published": "2026-08-14",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/2wsjf65enhy5h.ris",
  "sources": [
    {
      "first_seen": "2026-11-12T15:22:43Z",
      "native_id": "MED:43009992",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/43009992"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1306|Cancer, Hypoxia, and Metabolism",
      "subfield": "oncology"
    }
  ],
  "title": "Interplay of non-coding RNAs with amino acid and glucose transporters within the solute carrier family in cancer: a review.",
  "title_text": "Interplay of non-coding RNAs with amino acid and glucose transporters within the solute carrier family in cancer: a review.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-13T03:20:44Z",
  "url": "https://research.draconitic.com/paper/2wsjf65enhy5h",
  "venue": "Cancer cell international",
  "versions": []
}