{
  "abstract": "Objective: To investigate whether lesion-specific perivascular fat attenuation index (FAI) is associated with CCTA-defined anatomically significant (≥50%) left anterior descending coronary artery (LAD) stenosis and to evaluate the diagnostic performance of a composite model integrating serum inflammatory biomarkers.\n\nMethods: We retrospectively analyzed 160 patients with suspected coronary artery disease (CAD) who underwent coronary computed tomography angiography (CCTA). Patients receiving anti-inflammatory medications were excluded. Lesion-specific perivascular FAI was measured around the LAD. The prespecified primary outcome was CCTA-defined anatomically significant LAD stenosis (≥50%), analysed as a binary variable. Multivariable logistic regression identified independent predictors, and the final model was internally evaluated with stratified 5-fold cross-validation, 10-fold cross-validation, and 1,000-bootstrap resampling. Model building was repeated within each resample. Calibration (slope, calibration-in-the-large, Brier score) and incremental discrimination (DeLong test) were assessed.\n\nResults: Patients with CCTA-defined anatomically significant stenosis (≥50%) had higher, less negative FAI values, higher hs-CRP and LDH levels, and a lower ApoA1/ApoB ratio than those with stenosis <50% (all P < 0.05). FAI correlated with stenosis both as a continuous percentage ( ρ = 0.54, P < 0.001) and as a binary ≥50% variable ( ρ = 0.64, P < 0.001), with less negative FAI values accompanying more severe stenosis. The final model identified FAI (OR = 1.055, 95% CI: 1.014–1.098), hs-CRP (OR = 1.063, 95% CI: 1.005–1.125), LDH (OR = 1.014, 95% CI: 1.005–1.023), and the ApoA1/ApoB ratio (OR = 0.209, 95% CI: 0.070–0.624) as independent predictors. The composite model achieved an AUC of 0.915 (95% CI: 0.865–0.965); internal validation yielded AUCs of 0.872 (5-fold), 0.881 (95% CI: 0.826–0.936; 10-fold), and 0.895 (95% CI: 0.848–0.942; bootstrap). On formal DeLong testing for correlated ROC curves, the composite model showed significantly better discrimination than hs-CRP alone ( P = 0.020) and than FAI alone ( P < 0.001).\n\nConclusions: Higher, less negative perivascular FAI values were associated with CCTA-defined anatomically significant LAD stenosis. A composite model integrating FAI, hs-CRP, LDH, and the ApoA1/ApoB ratio showed high apparent diagnostic accuracy and remained stable across multiple internal validation strategies. Because this was a single-centre retrospective study without external validation or outcome data, these findings should be regarded as preliminary and hypothesis-generating; the model is not ready for clinical use.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Radiology, The First People’s Hospital of Kashi Prefecture",
    "Centre for Translational Medicine, Nanjing Medical University Affiliated Kizilsu People’s Hospital"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yiliya Ahongjiang"
    },
    {
      "affs": [
        0
      ],
      "name": "Alimujiang Abudukaiyoumu"
    },
    {
      "affs": [
        1
      ],
      "name": "Gulinuer Abulimiti"
    },
    {
      "affs": [
        0
      ],
      "name": "Hamisiguli Tuerxun"
    },
    {
      "affs": [
        0
      ],
      "name": "Aibibulajiang Mutailifu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2wsvp3z2zrjm2.bib",
  "cited_by": 0,
  "doi": "10.3389/fcvm.2026.1823667",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13724379/?tool=EBI",
  "id": "2wsvp3z2zrjm2",
  "issns": [
    "2297-055X"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fcvm.2026.1823667/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
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      "heading",
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      "openalex",
      "2705|Cardiovascular Disease and Adiposity"
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  "pdf_url": "https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2026.1823667/pdf",
  "pmcid": "PMC13724379",
  "pmid": "42973467",
  "published": "2026-10-19",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/2wsvp3z2zrjm2.ris",
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      "url": "https://www.frontiersin.org/articles/10.3389/fcvm.2026.1823667/full"
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      "origin": "openalex:2705|Cardiovascular Disease and Adiposity",
      "subfield": "cardiovascular"
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  "title": "Association between the perivascular fat attenuation index and CCTA-defined anatomically significant left anterior descending coronary artery stenosis: relationship with serum inflammatory biomarkers",
  "title_text": "Association between the perivascular fat attenuation index and CCTA-defined anatomically significant left anterior descending coronary artery stenosis: relationship with serum inflammatory biomarkers",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:20:52Z",
  "url": "https://research.draconitic.com/paper/2wsvp3z2zrjm2",
  "venue": "Frontiers in Cardiovascular Medicine",
  "versions": []
}