{
  "abstract": "Objective\n\nNeonatal respiratory distress syndrome (NRDS) is a common respiratory disease. This study aimed to detect the expression of miR-125b-5p in the umbilical cord blood of NRDS patients and to evaluate its diagnostic and prognostic value.Methods\n\nFluorescence-based real-time quantitative polymerase chain reaction was used to detect miR-125b-5p expression in the umbilical cord blood of NRDS patients and controls. The correlation between miR-125b-5p expression and NRDS clinical data was analyzed. Survival was analyzed using the Kaplan-Meier method. Cox regression identified risk factors for adverse outcomes, and the ROC curve evaluated diagnostic and prognostic accuracy.Results\n\nThe level of miR-125b-5p in NRDS patients was higher than that in controls. High miR-125b-5p expression was correlated with C-reactive protein levels, umbilical artery blood gas parameters, and the lung ultrasound score. Patients with high miR-125b-5p expression had significantly shorter event-free survival (HR 2.358, 95%CI 1.345-4.133, p<0.05) and long-term survival (HR 2.489, 95%CI 1.201-5.161, p<0.05). Cox regression identified high miR-125b-5p expression, high lung ultrasound score, high PaCO₂, and high PaO₂ as prognostic factors.Conclusions\n\nUmbilical cord blood miR-125b-5p is highly expressed in NRDS. It may serve as a biomarker for the diagnosis and prognosis of NRDS.",
  "abstract_shown": true,
  "affiliations": [
    "Shengli Oilfield Central Hospital, Shandong, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yang Zhang",
      "orcid": "0009-0002-6145-368X"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhiqiang Liu",
      "orcid": "0009-0000-5191-9605"
    },
    {
      "affs": [
        0
      ],
      "name": "Yanchun Zhang",
      "orcid": "0009-0000-7814-7334"
    },
    {
      "affs": [
        0
      ],
      "name": "Yanan Hou",
      "orcid": "0009-0007-7793-1507"
    },
    {
      "affs": [
        0
      ],
      "name": "Lushuang Sun",
      "orcid": "0009-0006-6396-8950"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2x1a63g86w0sx.bib",
  "cited_by": 0,
  "doi": "10.1590/1984-0462/2026/44/2025344",
  "fulltext_url": "https://europepmc.org/articles/PMC13682715",
  "id": "2x1a63g86w0sx",
  "issns": [
    "0103-0582",
    "1984-0462"
  ],
  "landing_url": "https://europepmc.org/article/MED/42912063",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2740|Neonatal Respiratory Health Research"
    ]
  ],
  "openalex": "W7222920236",
  "pdf_url": "https://europepmc.org/articles/PMC13682715?pdf=render",
  "pmcid": "PMC13682715",
  "pmid": "42912063",
  "published": "2026-10-19",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/2x1a63g86w0sx.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:10Z",
      "native_id": "MED:42912063",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42912063"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Neonatal Respiratory Health Research",
      "subfield": "general"
    }
  ],
  "title": "Umbilical cord blood miR-125b-5p: a diagnostic and prognostic biomarker for neonatal respiratory distress syndrome.",
  "title_text": "Umbilical cord blood miR-125b-5p: a diagnostic and prognostic biomarker for neonatal respiratory distress syndrome.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:10Z",
  "url": "https://research.draconitic.com/paper/2x1a63g86w0sx",
  "venue": "Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo",
  "versions": []
}