{
  "abstract": "Proper localization of proteins and RNAs in a cell is crucial for physiological function and cellular homeostasis, while disruption of the nucleocytoplasmic transport machinery leads to carcinogenesis. In gynaecological (endometrial, cervical and ovarian) tumours, upregulated nuclear transport protein expression promotes malignant cell proliferation, invasion and resistance to therapy. Therefore, therapeutic targeting of nuclear transport proteins has emerged as a promising anticancer approach. Researchers have extensively studied both nuclear import and export inhibitors in preclinical settings, alone or in combination with other targeted therapy agents. However, to date, only one compound, the exportin 1 inhibitor Selinexor, has been approved for cancer treatment. The development of nuclear transport inhibition-based therapies is hindered by limited inhibitor specificity and complex cellular resistance mechanisms. The aim of the present review was to clarify the connection between nuclear transport dysregulation, hallmarks of gynaecological tumours and the challenges of inhibiting nuclear transport in gynaecological cancer treatment.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Biochemistry and Molecular Biology, Institute of Biosciences, Life Sciences Center, Vilnius University, LT-10257 Vilnius, Lithuania",
    "Laboratory of Molecular Oncology, National Cancer Institute, LT-08406 Vilnius, Lithuania",
    "Faculty of Medicine, Vilnius University, LT-03101 Vilnius, Lithuania",
    "Department of Functional Materials and Electronics, Center for Physical Sciences and Technology, LT-10257 Vilnius, Lithuania"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ieva Norkaityte"
    },
    {
      "affs": [
        0
      ],
      "name": "Laura Marija Racyte"
    },
    {
      "affs": [
        1
      ],
      "name": "Egle Balciunaite"
    },
    {
      "affs": [
        2
      ],
      "name": "Aiste Avizaite"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Egle Zalyte"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2x7eyzexhjrcm.bib",
  "cited_by": 0,
  "doi": "10.3892/ijo.2026.5945",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13713053/",
  "id": "2x7eyzexhjrcm",
  "issns": [
    "1019-6439",
    "1791-2423"
  ],
  "landing_url": "https://doi.org/10.3892/ijo.2026.5945",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "1312|Nuclear Structure and Function"
    ]
  ],
  "openalex": "W7221015840",
  "pdf_url": null,
  "pmcid": "PMC13713053",
  "pmid": "42852615",
  "published": "2026-10-08",
  "publisher": "Spandidos Publications",
  "ris": "https://research.draconitic.com/paper/2x7eyzexhjrcm.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:23:31Z",
      "native_id": "PMC13713053",
      "source": "pmc",
      "url": "https://doi.org/10.3892/ijo.2026.5945"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Nuclear Structure and Function",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Nucleocytoplasmic transport in gynaecological cancer: From mechanisms to therapeutic potential (Review)",
  "title_text": "Nucleocytoplasmic transport in gynaecological cancer: From mechanisms to therapeutic potential (Review)",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:23:31Z",
  "url": "https://research.draconitic.com/paper/2x7eyzexhjrcm",
  "venue": "International Journal of Oncology",
  "versions": []
}