{
  "abstract": "Background\n\nβ-thalassemia major is a hereditary disorder characterized by transfusion-dependent anemia and associated complications. In patients with β-thalassemia major, one of the long-term complications of regular blood transfusion is renal dysfunction. This study aimed to evaluate serum β2-microglobulin as a marker of the severity of renal tubular dysfunction and to examine the clinical factors associated with the severity of renal tubular dysfunction in children with β-thalassemia major.Methods\n\nThis cross-sectional analytical study was conducted on 134 non-diabetic children with β-thalassemia major who attended thalassemia centers in Mazandaran Province, Iran. Data were collected using a structured checklist that included demographic information, laboratory findings, and clinical parameters. The severity of renal tubular dysfunction was assessed using serum β2-microglobulin levels. Glomerular filtration rate was estimated using the revised Schwartz formula. Pearson correlation analysis was used for statistical analysis.Results\n\nA significant positive correlation was observed between β2-microglobulin levels and age (r = 0.311, p < 0.001), number of blood transfusions per year (r = 0.390, p < 0.001), serum creatinine (r = 0.732, p < 0.001), blood urea nitrogen (r = 0.715, p < 0.001), and serum ferritin (r = 0.505, p < 0.001). In contrast, significant negative correlations were found with serum hemoglobin (r = -0.433, p < 0.001) and creatinine clearance (r = -0.383, p < 0.001).Conclusion\n\nRenal tubular dysfunction in children with β-thalassemia major showed significant correlations with age, iron overload, anemia severity, and transfusion frequency. Serum β2-microglobulin may serve as a useful marker for the early detection of tubular damage and may help guide preventive strategies in clinical practice.",
  "abstract_shown": true,
  "affiliations": [
    "Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.",
    "Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.",
    "Student Research Committee, Babol University of Medical Sciences, Babol, Iran.",
    "Clinical Research Development Unit of Amirkola Children's Hospital, Babol University of Medical Sciences, Babol, IR Iran."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Roghayeh Akbari"
    },
    {
      "affs": [
        1
      ],
      "name": "Hassan Mahmoodi Nesheli"
    },
    {
      "affs": [
        2
      ],
      "name": "Soha Salehi"
    },
    {
      "affs": [
        3
      ],
      "name": "Mahmoud Hajiahmadi"
    },
    {
      "affs": [
        1
      ],
      "name": "Sahar Sadr Moharerpour"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2xqv9hsswpnxz.bib",
  "cited_by": 0,
  "doi": "10.22088/cjim.17.3.546",
  "fulltext_url": "https://europepmc.org/articles/PMC13689546",
  "id": "2xqv9hsswpnxz",
  "issns": [
    "2008-6164",
    "2008-6172"
  ],
  "landing_url": "https://europepmc.org/article/MED/42923635",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2716|Hemoglobinopathies and Related Disorders"
    ]
  ],
  "openalex": "W7216722661",
  "pdf_url": "https://europepmc.org/articles/PMC13689546?pdf=render",
  "pmcid": "PMC13689546",
  "pmid": "42923635",
  "published": "2026-09-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/2xqv9hsswpnxz.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:02Z",
      "native_id": "MED:42923635",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42923635"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2716|Hemoglobinopathies and Related Disorders",
      "subfield": "human-genetics"
    }
  ],
  "title": "Serum β2-microglobulin as a marker of renal tubular damage in transfusion-dependent β-thalassemia.",
  "title_text": "Serum β2-microglobulin as a marker of renal tubular damage in transfusion-dependent β-thalassemia.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:02Z",
  "url": "https://research.draconitic.com/paper/2xqv9hsswpnxz",
  "venue": "Caspian journal of internal medicine",
  "versions": []
}