{
  "abstract": "Thalassaemia remains a major public health burden in Asia, where high carrier frequencies, diverse mutation spectra, and variable healthcare capacity continue to influence disease prevention and control. This Series paper summarises the status of thalassaemia prevention programmes across 14 Asian countries and highlights the key challenges and opportunities affecting their implementation. Singapore, Malaysia, the Maldives, and Thailand have established the most structured prevention strategies, incorporating combinations of public awareness, carrier screening, genetic counselling, and prenatal diagnosis, with measurable success most clearly demonstrated in Singapore and, to a specific extent, Thailand. In contrast, many other countries in the region continue to face fragmented services, limited national coordination, shortages of trained personnel, inadequate epidemiological data, and financial, technological, cultural, and social barriers. Differences in prevention efforts broadly reflect wider disparities in health system development. Strengthening national prevention programmes should be viewed as both a public health priority and a cost-effective investment in reducing long-term disease burden.",
  "abstract_shown": true,
  "affiliations": [
    "Thalassaemia International Federation, Nicosia, Cyprus.",
    "Thalassemia Research Center, Institute of Molecular Biosciences, Mahidol University and Samitvej Srinakarin Hospital, Bangkok, Thailand.",
    "Thalassemia Research Center, Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, Thailand.",
    "National Institute of Haematology and Blood Transfusion and Hanoi Medical University, Hanoi, Viet Nam.",
    "Thalassemia Centre, National Institute of Haematology and Blood Transfusion, Hanoi, Viet Nam.",
    "National Thalassemia Registry, Department of Genomic Medicine, KK Women's and Children's Hospital, Singapore.",
    "Pediatric Hematology-Oncology Division, Department of Child Health, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia.",
    "Department of Paediatrics, University of Health Sciences, Vientiane, Laos.",
    "Department of Pediatrics, Raja Isteri Pengiran Anak Saleha Hospital, Bandar Seri Begawan, Brunei Darussalam.",
    "Department of Pediatric Hematology - Immunology and Transfusion Medicine, National Pediatric Hospital, University of Health Sciences, Phnom Penh, Cambodia.",
    "Thalassemia Action Network, Philippine Society of Hematology and Blood Transfusion, Blood and Cancer Care Center, National Children's Hospital, Manila, Philippines.",
    "Department of Pediatric Hematology Oncology, Post Graduate Institute of Child Health (PGICH), Delhi NCR, Noida, India.",
    "Center for Research on Rare Blood Disorders (CR-RBD) and Thalassemia & Sickle Cell Center, Burjeel Cancer Institute, Burjeel Medical City, Abu Dhabi, United Arab Emirates.",
    "Department of Public Health & Epidemiology, Khalifa University, Abu Dhabi, United Arab Emirates.",
    "Division of Hematology/Oncology, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Michael Angastiniotis"
    },
    {
      "affs": [
        1
      ],
      "name": "Suthat Fucharoen"
    },
    {
      "affs": [
        2
      ],
      "name": "Kittiphong Paiboonsukwong"
    },
    {
      "affs": [
        3
      ],
      "name": "Ha Thanh Nguyen"
    },
    {
      "affs": [
        4
      ],
      "name": "Thi Thu Ha Nguyen"
    },
    {
      "affs": [
        5
      ],
      "name": "Hai Yang Law"
    },
    {
      "affs": [
        6
      ],
      "name": "Pustika Amalia Wahidiyat"
    },
    {
      "affs": [
        7
      ],
      "name": "Sourideth Sengchanh"
    },
    {
      "affs": [
        8
      ],
      "name": "Norehan Johari"
    },
    {
      "affs": [
        9
      ],
      "name": "Chean Sophâl"
    },
    {
      "affs": [
        10
      ],
      "name": "Maria Liza T Naranjo"
    },
    {
      "affs": [
        11
      ],
      "name": "Nita Radhakrishnan"
    },
    {
      "affs": [
        12,
        13,
        14
      ],
      "name": "Khaled M Musallam"
    },
    {
      "affs": [
        0
      ],
      "name": "Androulla Eleftheriou"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2y2htcfkv61fz.bib",
  "cited_by": 0,
  "doi": "10.1016/j.lansea.2026.100810",
  "fulltext_url": "https://europepmc.org/articles/PMC13680628",
  "id": "2y2htcfkv61fz",
  "issns": [
    "2772-3682"
  ],
  "landing_url": "https://europepmc.org/article/MED/42903198",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2716|Hemoglobinopathies and Related Disorders"
    ]
  ],
  "openalex": "W7220674095",
  "pdf_url": "https://europepmc.org/articles/PMC13680628?pdf=render",
  "pmcid": "PMC13680628",
  "pmid": "42903198",
  "published": "2026-10-06",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/2y2htcfkv61fz.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:57Z",
      "native_id": "MED:42903198",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42903198"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2716|Hemoglobinopathies and Related Disorders",
      "subfield": "human-genetics"
    }
  ],
  "title": "Thalassaemia prevention in Asia: progress, challenges, and future directions.",
  "title_text": "Thalassaemia prevention in Asia: progress, challenges, and future directions.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:57Z",
  "url": "https://research.draconitic.com/paper/2y2htcfkv61fz",
  "venue": "The Lancet regional health. Southeast Asia",
  "versions": []
}