{
  "abstract": "Low-affinity transcription factor binding sites are functionally important but difficult to map and mechanistically poorly understood. In this issue of Cell Genomics, Weilert et al. leverage sequence-to-function deep learning models to systematically map low-affinity pioneer factor binding sites in mouse embryonic stem cells and reveal how these sites contribute to chromatin opening through soft-syntax nucleosomal cooperativity.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, USA.",
    "Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, USA; Department of Systems Biology, University of California, Irvine, Irvine, CA, USA. Electronic address: ekvon@uci.edu."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Grace Bower"
    },
    {
      "affs": [
        1
      ],
      "name": "Evgeny Z Kvon"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2y38jhk15kd96.bib",
  "cited_by": 0,
  "doi": "10.1016/j.xgen.2026.101392",
  "fulltext_url": "https://europepmc.org/articles/PMC13689512",
  "id": "2y38jhk15kd96",
  "issns": [
    "2666-979X"
  ],
  "landing_url": "https://europepmc.org/article/MED/42874569",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Genomics and Chromatin Dynamics"
    ]
  ],
  "openalex": "W7221762087",
  "pdf_url": "https://europepmc.org/articles/PMC13689512?pdf=render",
  "pmcid": "PMC13689512",
  "pmid": "42874569",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/2y38jhk15kd96.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:00Z",
      "native_id": "MED:42874569",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42874569"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Genomics and Chromatin Dynamics",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Deep learning uncovers hidden power of low-affinity motifs.",
  "title_text": "Deep learning uncovers hidden power of low-affinity motifs.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:00Z",
  "url": "https://research.draconitic.com/paper/2y38jhk15kd96",
  "venue": "Cell genomics",
  "versions": []
}