{
  "abstract": "Peripheral artery disease (PAD) ranges from intermittent claudication to critical limb‑threatening ischemia (CLTI), with <3% of intermittent claudication cases progressing to CLTI. This study aimed to compare the outcomes of percutaneous transluminal angioplasty with stenting (PTAS) and synthetic graft femoropopliteal bypass (FPB) in a homogeneous PAD cohort. A subgroup analysis of TransAtlantic Inter-Society Consensus (TASC) B and C lesions, which lack standardized treatment algorithms, was also performed. We retrospectively analyzed 88 patients with no prior history of vascular interventions in the same limb who were treated for isolated superficial femoral artery lesions between 2016 and 2020 (29 underwent PTAS and 59 underwent FPB). Primary outcomes were reintervention, limb amputation, mortality, and vessel patency (primary, assisted primary, and secondary) over a 3‑year follow‑up. Subgroup analysis was performed to assess differences in treatment outcomes. No statistically significant differences were detected in reintervention, limb amputation, mortality, or patency between the two treatments. For loss of primary patency, the hazard ratio (HR) for FPB versus PTAS was 1.89 (95% confidence interval [CI], 0.76–4.69; log-rank p = 0.146) and 1.23 (95% CI, 0.45–3.38) after adjustment for lesion length and TASC grade. In the TASC B and C subgroup, no significant differences were observed in primary, assisted primary, or secondary patency (log-rank p = 0.809, 0.302, and 0.135, respectively). The study was underpowered to detect modest effects (post-hoc power for primary patency, 34.4%). In this small single-center cohort, no statistically significant difference in 3-year outcomes was detected between PTAS and FPB for isolated superficial femoral artery lesions; clinically meaningful differences cannot be excluded, and the findings should be regarded as hypothesis-generating.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Thoracic and Cardiovascular Surgery, Pusan National University School of Medicine, Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea",
    "Medical Research Institute, Pusan National University School of Medicine, Yangsan, Republic of Korea",
    "Department of Family Medicine, Pusan National University School of Medicine, Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea",
    "In Silico Medicine Lab, Biomedical Research Institute, Pusan National University School of Medicine, Busan, Republic of Korea",
    "Department of Emergency Medicine, Pusan National University School of Medicine, Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea"
  ],
  "article_type": "Research Article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Changsung Han"
    },
    {
      "affs": [
        1
      ],
      "name": "Gwon-Min Kim"
    },
    {
      "affs": [
        2
      ],
      "name": "Jaewon Choi"
    },
    {
      "affs": [
        3
      ],
      "name": "Young Jin Tak"
    },
    {
      "affs": [
        4
      ],
      "name": "Chiseung Lee"
    },
    {
      "name": "Chung Won Lee"
    },
    {
      "name": "Miju Bae"
    },
    {
      "name": "Il Jae Wang"
    },
    {
      "name": "Up Huh"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2y4evmxd6szgy.bib",
  "cited_by": 0,
  "doi": "10.1371/journal.pone.0361589",
  "fulltext_url": null,
  "id": "2y4evmxd6szgy",
  "issns": [
    "1932-6203"
  ],
  "landing_url": "https://doi.org/10.1371/journal.pone.0361589",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "plos",
      "/Biology and life sciences/Anatomy/Cardiovascular anatomy/Blood vessels/Arteries"
    ],
    [
      "plos",
      "/Biology and life sciences/Anatomy/Cardiovascular anatomy/Blood vessels/Arteries/Femoral arteries"
    ],
    [
      "plos",
      "/Biology and life sciences/Physiology/Physiological parameters/Body weight"
    ],
    [
      "plos",
      "/Medicine and health sciences/Anatomy/Cardiovascular anatomy/Blood vessels/Arteries"
    ],
    [
      "plos",
      "/Medicine and health sciences/Anatomy/Cardiovascular anatomy/Blood vessels/Arteries/Femoral arteries"
    ],
    [
      "plos",
      "/Medicine and health sciences/Clinical medicine/Signs and symptoms/Lesions"
    ],
    [
      "plos",
      "/Medicine and health sciences/Endocrinology/Endocrine disorders/Diabetes mellitus"
    ],
    [
      "plos",
      "/Medicine and health sciences/Medical conditions/Metabolic disorders/Diabetes mellitus"
    ],
    [
      "plos",
      "/Medicine and health sciences/Surgical and invasive medical procedures"
    ],
    [
      "plos",
      "/Medicine and health sciences/Surgical and invasive medical procedures/Cardiovascular procedures/Vascular surgery"
    ],
    [
      "plos",
      "/Medicine and health sciences/Surgical and invasive medical procedures/Stent implantation"
    ]
  ],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-05",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/2y4evmxd6szgy.ris",
  "sources": [
    {
      "first_seen": "2026-11-06T12:20:42Z",
      "native_id": "10.1371/journal.pone.0361589",
      "source": "plos",
      "url": "https://doi.org/10.1371/journal.pone.0361589"
    }
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  "subjects": [
    {
      "field": "medicine",
      "origin": "plos:anatomy",
      "subfield": "physiology"
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    {
      "field": "medicine",
      "origin": "plos:surgical and invasive medical procedures",
      "subfield": "surgery"
    }
  ],
  "title": "Comparative outcomes of endovascular versus synthetic bypass for isolated superficial femoral artery lesions: A 3-year single-center cohort study",
  "title_text": "Comparative outcomes of endovascular versus synthetic bypass for isolated superficial femoral artery lesions: A 3-year single-center cohort study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:20:24Z",
  "url": "https://research.draconitic.com/paper/2y4evmxd6szgy",
  "venue": "PLOS One",
  "versions": []
}