{
  "abstract": "Background and objectives: Subclinical myocardial deformation abnormalities may be detectable during long-term follow-up in pediatric patients with a history of myopericarditis despite apparently normal conventional echocardiographic findings. This study aimed to comprehensively evaluate long-term myocardial deformation abnormalities using speckle-tracking echocardiography and to assess their associations with acute-phase inflammatory and cardiac biomarkers.\n\nMethods: Thirty pediatric patients with a history of myopericarditis and 22 age- and sex-matched healthy controls were included. Acute-phase clinical, laboratory, electrocardiographic, and echocardiographic data were retrospectively collected. At long-term follow-up, comprehensive echocardiographic evaluation including tissue Doppler imaging and speckle-tracking–derived longitudinal and circumferential strain analysis was prospectively performed. Associations between acute-phase biomarkers and long-term echocardiographic findings were analyzed.\n\nResults: At a mean follow-up of 32.8 ± 12.0 months, patients demonstrated significantly reduced global longitudinal strain (−12.43 ± 6.67% vs. −17.77 ± 1.94%, p < 0.001) and global circumferential strain (−16.04 ± 12.50% vs. −25.14 ± 4.73%, p = 0.002) compared with controls despite largely preserved conventional systolic function. Segmental longitudinal and circumferential strain parameters were also impaired, accompanied by increased time-to-peak strain dispersion. Higher neutrophil-to-lymphocyte ratio and systemic immune-inflammation index values correlated with less negative global longitudinal strain values, while CRP correlated with impaired global circumferential strain.\n\nConclusions: Pediatric patients with a history of myopericarditis may exhibit subclinical myocardial deformation abnormalities at long-term follow-up despite apparently preserved conventional echocardiographic findings. Speckle-tracking echocardiography may provide incremental value for detecting subtle myocardial deformation abnormalities beyond conventional systolic assessment. Exploratory associations were observed between acute-phase inflammatory biomarkers and long-term myocardial deformation parameters; however, larger prospective studies are needed to clarify whether these findings have causal or clinical significance.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pediatric Cardiology, Kosuyolu Yuksek Ihtisas Egitim ve Arastirma Hastanesi",
    "Department of Pediatric Cardiology, Marmara Universitesi Tip Fakultesi",
    "Department of Pediatric Cardiology, Ankara Etlik Entegre Saglik Kampusu"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Sule Arici"
    },
    {
      "affs": [
        1
      ],
      "name": "Selen Karagozlu"
    },
    {
      "affs": [
        2
      ],
      "name": "Elif Erolu Kibris"
    },
    {
      "affs": [
        1
      ],
      "name": "Figen Akalın"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2yd9v43xd4dnh.bib",
  "cited_by": 0,
  "doi": "10.3389/fcvm.2026.1938858",
  "fulltext_url": null,
  "id": "2yd9v43xd4dnh",
  "issns": [
    "2297-055X"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fcvm.2026.1938858/full",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2705|Viral Infections and Immunology Research"
    ]
  ],
  "openalex": "W7224130660",
  "pdf_url": "https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2026.1938858/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-28",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/2yd9v43xd4dnh.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:10Z",
      "native_id": "10.3389/fcvm.2026.1938858",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fcvm.2026.1938858/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Viral Infections and Immunology Research",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Long-term myocardial deformation abnormalities and biomarker associations in pediatric myopericarditis: a speckle-tracking echocardiographic study",
  "title_text": "Long-term myocardial deformation abnormalities and biomarker associations in pediatric myopericarditis: a speckle-tracking echocardiographic study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:10Z",
  "url": "https://research.draconitic.com/paper/2yd9v43xd4dnh",
  "venue": "Frontiers in Cardiovascular Medicine",
  "versions": []
}