{
  "abstract": "Nucleotide excision repair (NER) is a critical DNA repair pathway responsible for removing bulky, helix-distorting DNA lesions, including ultraviolet radiation-induced photoproducts and platinum drug-DNA adducts. This review provides a comprehensive overview of current understanding of NER in cancer, with particular emphasis on its role in therapeutic response. We discuss the molecular mechanisms of DNA repair in cancer, the significance of NER in platinum-based therapies, results from in vitro studies across various cancer types, findings from patient-based studies, and outcomes from clinical trials. Special attention is given to ERCC1, ERCC2/XPD, XPA, and XPC molecules as potential biomarkers of treatment response and therapeutic targets, and incorporating the most recent discoveries regarding NER inhibitors, mutational signatures, and synthetic lethality-based approaches.",
  "abstract_shown": true,
  "affiliations": [
    "Radiobiology Laboratory, Greater Poland Cancer Centre, Garbary 15 Street, Poznan, 61-866, Poland. barmackowiak@gmail.com.",
    "Doctoral School of Molecular Medicine, Medical University of Lodz, Haller Square 1, Lodz, 90-624, Poland. barmackowiak@gmail.com.",
    "Radiobiology Laboratory, Greater Poland Cancer Centre, Garbary 15 Street, Poznan, 61-866, Poland.",
    "Department of Clinical Chemistry and Molecular Diagnostics, Poznan University of Medical Sciences, Rokietnicka 3 Street, Poznan, 60-806, Poland.",
    "Department of Head and Neck Surgery, Poznan University of Medical Sciences, Garbary 15 Street, Poznan, 61-866, Poland.",
    "Department of Electroradiology, Poznan University of Medical Sciences, Fredry 10 Street, Poznan, 61-701, Poland."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Bartosz Maćkowiak",
      "orcid": "0009-0009-6786-5707"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Kamila Ostrowska"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Julia Kozikowska"
    },
    {
      "affs": [
        2
      ],
      "name": "Katarzyna Kulcenty"
    },
    {
      "affs": [
        4
      ],
      "name": "Wojciech Golusiński"
    },
    {
      "affs": [
        2,
        5
      ],
      "name": "Wiktoria Suchorska"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2ydtamqp9vs50.bib",
  "cited_by": 0,
  "doi": "10.1007/s00432-026-06563-0",
  "fulltext_url": "https://europepmc.org/articles/PMC13677657",
  "id": "2ydtamqp9vs50",
  "issns": [
    "0171-5216",
    "1432-1335"
  ],
  "landing_url": "https://europepmc.org/article/MED/42894078",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC254-282"
    ],
    [
      "openalex",
      "1312|DNA Repair Mechanisms"
    ]
  ],
  "openalex": "W7170086799",
  "pdf_url": "https://europepmc.org/articles/PMC13677657?pdf=render",
  "pmcid": "PMC13677657",
  "pmid": "42894078",
  "published": "2026-07-01",
  "publisher": "Springer",
  "ris": "https://research.draconitic.com/paper/2ydtamqp9vs50.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:42Z",
      "native_id": "MED:42894078",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42894078"
    },
    {
      "first_seen": "2026-10-30T13:45:36Z",
      "native_id": "b61151aa32c446e1ac9e39a4a7552456",
      "source": "doaj",
      "url": "https://doi.org/10.1007/s00432-026-06563-0"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|DNA Repair Mechanisms",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Nucleotide excision repair in tumor response to DNA-damaging anticancer therapies: a comprehensive review.",
  "title_text": "Nucleotide excision repair in tumor response to DNA-damaging anticancer therapies: a comprehensive review.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:45:36Z",
  "url": "https://research.draconitic.com/paper/2ydtamqp9vs50",
  "venue": "Journal of cancer research and clinical oncology",
  "versions": []
}