{
  "abstract": "This retrospective study evaluated the diagnostic screening and early identification value of admission baseline cardiac and renal biomarkers for newly developed in-hospital type 1 cardiorenal syndrome (CRS) after acute myocardial infarction (AMI). Baseline samples were collected at emergency admission before the documented onset of renal injury. A total of 150 AMI patients were included, comprising 60 patients who developed incident CRS and 90 AMI controls without renal impairment. Laboratory indicators included cardiac markers (cardiac troponin I [cTnI] and N-terminal pro-B-type natriuretic peptide [NT-proBNP]) and renal-related markers including retinol-binding protein (RBP), urea, serum creatinine and spot urinary microalbumin. Multivariate logistic regression adjusted for infarct size, haemodynamic status, baseline renal function, comorbidities and guideline-directed cardiovascular medications, and ROC analysis assessed discriminatory performance. Baseline urea, urinary microalbumin and NT-proBNP were higher, while RBP was lower, in patients who developed CRS (all P < 0.0001). Independently associated indicators included cTnI (OR = 0.628, 95% CI: 0.436–0.903, P = 0.012), RBP (OR = 0.931, 95% CI: 0.883–0.981, P = 0.008), urea (OR = 1.226, 95% CI: 1.039–1.446, P = 0.016) and urinary microalbumin (OR = 1.017, 95% CI: 1.004–1.031, P = 0.013). Urea showed the highest AUC (0.914; sensitivity, 78.5%; specificity, 83.4%). Raw urinary microalbumin showed an AUC of 0.747, and urinary microalbumin showed improved discriminatory performance after urine creatinine calibration and covariate adjustment (AUC = 0.883). Combined assessment of these biomarkers may support diagnostic screening of AMI patients at increased risk of in-hospital CRS.",
  "abstract_shown": true,
  "affiliations": [
    "Laboratory Department, the 964th Hospital of the Joint Logistics Support Force, No. 4799 Xi’an Road, lvyuan District, Changchun, Jilin Province 130000 China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ge Guo"
    },
    {
      "affs": [
        0
      ],
      "name": "Yun Zhao"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2ygdf7v126wpe.bib",
  "cited_by": 0,
  "doi": "10.1186/s12872-026-06350-2",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13729441/",
  "id": "2ygdf7v126wpe",
  "issns": [
    "1471-2261"
  ],
  "landing_url": "https://doi.org/10.1186/s12872-026-06350-2",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "openalex",
      "2705|Acute Myocardial Infarction Research"
    ]
  ],
  "openalex": "W7196977340",
  "pdf_url": null,
  "pmcid": "PMC13729441",
  "pmid": "42977942",
  "published": "2026-08-07",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/2ygdf7v126wpe.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T12:22:12Z",
      "native_id": "PMC13729441",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s12872-026-06350-2"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Acute Myocardial Infarction Research",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Admission cardiac and renal biomarkers for early identification of type 1 cardiorenal syndrome after acute myocardial infarction",
  "title_text": "Admission cardiac and renal biomarkers for early identification of type 1 cardiorenal syndrome after acute myocardial infarction",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:22:12Z",
  "url": "https://research.draconitic.com/paper/2ygdf7v126wpe",
  "venue": "BMC Cardiovascular Disorders",
  "versions": []
}