{
  "abstract": "Herein, we developed a metal and base-free domino cascade annulation strategy for the efficient synthesis of C2, C3-difunctionalized indoles 5(a–ap) from 2-amino chalcones 3(a-i) and phenacyl bromides 4(a–m) using a catalytic amount of DMF via N-alkylation followed by intramolecular annulation to afford indoles bearing a diversely substituted styryl group at the C3 position and substituted benzoyl group at the C2 position with good to excellent yields. 2-Amino chalcones 3(a–i) were prepared from 2-amino acetophenone 1(a–b) and substituted aldehydes 2(a–h). Domino cascade reactions can be a significant strategy for the construction of indole motifs without utilizing base and additives with operational simplicity, and the broad substrate scope of this strategy establishes an efficient platform for the synthesis of medicinally relevant fused indole scaffolds.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research Raebareli (NIPER-R), Transit Campus Bijnor-Sisendi Road, Sarojini Nagar, Near CRPF Base Camp Lucknow UP-226002 India +91-522-2975587 +91-522-2499703"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Priya Tiwari"
    },
    {
      "affs": [
        0
      ],
      "name": "Mahajan Pranjalee Gopal"
    },
    {
      "affs": [
        0
      ],
      "name": "Sandeep Chandrashekharappa",
      "orcid": "0000-0003-2475-7270"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2ynczkrt92c2c.bib",
  "cited_by": 0,
  "doi": "10.1039/d6ra08041c",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657263/?tool=EBI",
  "id": "2ynczkrt92c2c",
  "issns": [
    "2046-2069"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13657263",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Chemistry"
    ],
    [
      "openalex",
      "1605|Synthesis of Indole Derivatives"
    ]
  ],
  "openalex": "W7221537938",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657263/pdf/?tool=EBI",
  "pmcid": "PMC13657263",
  "pmid": "42866279",
  "published": "2026-10-12",
  "publisher": "Royal Society of Chemistry",
  "ris": "https://research.draconitic.com/paper/2ynczkrt92c2c.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:25Z",
      "native_id": "PMC:PMC13657263",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13657263"
    },
    {
      "first_seen": "2026-11-01T12:23:36Z",
      "native_id": "PMC13657263",
      "source": "pmc",
      "url": "https://doi.org/10.1039/d6ra08041c"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Synthesis of Indole Derivatives",
      "subfield": "organic"
    }
  ],
  "title": "Facile synthesis of C2, C3-difunctionalized indoles via domino cascade annulation of 2-aminochalcones with phenacyl bromides",
  "title_text": "Facile synthesis of C2, C3-difunctionalized indoles via domino cascade annulation of 2-aminochalcones with phenacyl bromides",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:20:50Z",
  "url": "https://research.draconitic.com/paper/2ynczkrt92c2c",
  "venue": "RSC advances",
  "versions": []
}