{
  "abstract": "Introduction\n\nThe Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB) develops resources for biomolecular structure exploration and analysis that are used by an interdisciplinary community of bio scientists, researchers, and students numbering in the many millions worldwide. The RCSB.org website and suite of APIs provide access to more than 250,000 experimentally determined structures archived in the PDB, making it an invaluable tool for biotechnology, such as research on plastic-degrading enzymes. Engineering plastic-degrading enzymes represents a promising strategy for mitigating environmental accumulation of polyethylene terephthalate (PET).Methods\n\nIn recent years, RCSB.org has provided access to more than 1 million Computed Structure Models (CSMs) alongside experimentally determined structures and introduced new tools for 3D Motif Search, Visualizing Sequence Annotations in 3D, and Pairwise Structure Alignment.Results and discussion\n\nTo identify site-directed mutagenesis targets for improving PET-degrading enzyme efficiency, biotechnology researchers utilize 3D structure data freely available from the PDB. This article describes how RCSB PDB tools for Advanced Search, Visualizing Sequence Annotations in 3D, and Pairwise Structure Alignment can be used to study plastic-degrading enzyme structure and function.",
  "abstract_shown": true,
  "affiliations": [
    "Research Collaboratory for Structural Bioinformatics Protein Data Bank, Rutgers, The State University of New Jersey, New Brunswick, NJ, United States.",
    "Institute for Quantitative Biomedicine, Rutgers, The State University of New Jersey, New Brunswick, NJ, United States.",
    "Research Collaboratory for Structural Bioinformatics Protein Data Bank, San Diego Supercomputer Center, University of California, La Jolla, CA, United States.",
    "Rutgers Cancer Institute, The State University of New Jersey, New Brunswick, NJ, United States.",
    "Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, New Brunswick, NJ, United States.",
    "Rutgers Artificial Intelligence and Data Science (RAD) Collaboratory, Rutgers, The State University of New Jersey, New Brunswick, NJ, United States."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
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        0,
        1
      ],
      "name": "Alison Biester"
    },
    {
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        1
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      "name": "Christine Zardecki"
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    {
      "affs": [
        2
      ],
      "name": "Yana Rose"
    },
    {
      "affs": [
        2
      ],
      "name": "Joan Segura"
    },
    {
      "affs": [
        2
      ],
      "name": "Jose M Duarte"
    },
    {
      "affs": [
        0,
        1,
        2,
        3,
        4,
        5
      ],
      "name": "Stephen K Burley"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2yr3yyf7kc6rj.bib",
  "cited_by": 0,
  "doi": "10.3389/fbioe.2026.1947029",
  "fulltext_url": "https://europepmc.org/articles/PMC13677904",
  "id": "2yr3yyf7kc6rj",
  "issns": [
    "2296-4185"
  ],
  "landing_url": "https://europepmc.org/article/MED/42898362",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2505|Enzyme Structure and Function"
    ]
  ],
  "openalex": "W7220477246",
  "pdf_url": "https://europepmc.org/articles/PMC13677904?pdf=render",
  "pmcid": "PMC13677904",
  "pmid": "42898362",
  "published": "2026-10-05",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/2yr3yyf7kc6rj.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:37Z",
      "native_id": "MED:42898362",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42898362"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2505|Enzyme Structure and Function",
      "subfield": "materials-polymers"
    }
  ],
  "title": "RCSB PDB web portal RCSB.org for biotechnology research: exploration and visualization of plastic-degrading enzymes at the atomic level in 3D.",
  "title_text": "RCSB PDB web portal RCSB.org for biotechnology research: exploration and visualization of plastic-degrading enzymes at the atomic level in 3D.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:37Z",
  "url": "https://research.draconitic.com/paper/2yr3yyf7kc6rj",
  "venue": "Frontiers in bioengineering and biotechnology",
  "versions": []
}