{
  "abstract": "The risk of venous thromboembolic events (VTE) is elevated in patients with active cancer. Recent antineoplastic therapies, including immunotherapies and targeted therapies, may further increase VTE risk, although evidence is limited. In March 2024, we conducted a disproportionality analysis using reporting odds ratios (Reporting-OR) in VigiBase, the World Health Organization's (WHO's) pharmacovigilance database, to assess the association between 280 antineoplastic therapies approved by the US Food and Drug Administration and/or the European Medicines Agency and VTE (symptomatic or not), defined as deep vein thrombosis and/or pulmonary embolism. Reporting-OR were adjusted (aReporting-OR) for case characteristics, including primary tumor site and metastatic status. A total of 37 803 VTE reports associated with at least 1 antineoplastic therapy were identified. We identified 19 antineoplastic therapies significantly associated with an increased reporting of VTE, with nintedanib emerging as a newly recognized association. The strongest associations were observed for lenalidomide (aReporting-OR, 3.64; 95% confidence interval [CI], 3.47-3.82), bevacizumab (aReporting-OR, 3.64; 95% CI, 3.43-3.86), and cyproterone (aReporting-OR, 3.52; 95% CI, 2.55-4.87). The median time to VTE onset was 64 days (interquartile range, 27-143), with 81% of VTE events occurring within the first 6 months after antineoplastic therapy initiation. Future studies should include antineoplastic therapies in VTE risk assessments and evaluate the management of VTE when recurrences occur while under treatment. This trial was registered at www.clinicaltrials.gov as NCT04696250.",
  "abstract_shown": true,
  "affiliations": [
    "Departments of Pharmacology and Medical Oncology, PICARO Cardio-oncology program, Université Caen Normandie, ANTICIPE UMR 1086, Centre Hospitalier Universitaire de Caen, Caen, France",
    "Department of Pharmacology, PICARO Cardio-Oncology Program, Université Caen Normandie, ANTICIPE UMR 1086, Centre Hospitalier Universitaire de Caen, Caen, France",
    "Service de Médecine Vasculaire et Thérapeutique, Centre Hospitalier Universitaire de St-Etienne, Saint-Etienne, France",
    "Vascular Medicine Department, Centre Hospitalier Universitaire de Caen Normandie, Caen, France",
    "Division of Biostatistics, Department of Advanced Medicine, Nagoya University Hospital, Nagoya, Japan",
    "Medical Oncology Department, Centre Hospitalier Universitaire de Caen Normandie, Caen, France",
    "Medical Oncology Department, Centre François Baclesse, Caen, France",
    "Cardiology Department, Centre Hospitalier Universitaire de Caen Normandie, Caen, France",
    "Department of Cardiology, PICARO Cardio-Oncology Program, Université Caen Normandie, ANTICIPE UMR 1086, Centre Hospitalier Universitaire de Caen, Caen, France",
    "Department of Pharmacology, Pharmaco-Epidemiology Unit, PICARO Cardio-Oncology Program, Université Caen Normandie, ANTICIPE UMR 1086, Centre Hospitalier Universitaire de Caen, Caen, France"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Angélique Da Silva"
    },
    {
      "affs": [
        1
      ],
      "name": "Joachim Alexandre"
    },
    {
      "affs": [
        2
      ],
      "name": "Laurent Bertoletti"
    },
    {
      "affs": [
        3
      ],
      "name": "Damien Laneelle"
    },
    {
      "affs": [
        3
      ],
      "name": "Flavie Biron"
    },
    {
      "affs": [
        4
      ],
      "name": "Basile Chrétien"
    },
    {
      "affs": [
        5
      ],
      "name": "Flavien Minoc"
    },
    {
      "affs": [
        6
      ],
      "name": "Mélanie Janson"
    },
    {
      "affs": [
        7
      ],
      "name": "Anne-Flore Plane"
    },
    {
      "affs": [
        8
      ],
      "name": "Damien Legallois"
    },
    {
      "affs": [
        9
      ],
      "name": "Charles Dolladille"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2yv5kf4a3sjts.bib",
  "cited_by": 0,
  "doi": "10.1016/j.bvth.2026.100212",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13717868/?tool=EBI",
  "id": "2yv5kf4a3sjts",
  "issns": [
    "2950-3272"
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  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Thrombotic Disorders: Clinical"
    ],
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      "openalex",
      "2724|Venous Thromboembolism Diagnosis and Management"
    ]
  ],
  "openalex": "W7208747232",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13717868/pdf/?tool=EBI",
  "pmcid": "PMC13717868",
  "pmid": "42960050",
  "published": "2026-09-04",
  "publisher": "The American Society of Hematology",
  "ris": "https://research.draconitic.com/paper/2yv5kf4a3sjts.ris",
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      "url": "https://doi.org/10.1016/j.bvth.2026.100212"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2724|Venous Thromboembolism Diagnosis and Management",
      "subfield": "general"
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  ],
  "title": "Antineoplastic therapies associated with venous thromboembolism: disproportionality analysis of the WHO database",
  "title_text": "Antineoplastic therapies associated with venous thromboembolism: disproportionality analysis of the WHO database",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:22:06Z",
  "url": "https://research.draconitic.com/paper/2yv5kf4a3sjts",
  "venue": "Blood vessels, thrombosis & hemostasis",
  "versions": []
}