{
  "abstract": "An HPLC-MS/MS method combining modified QuEChERS-based extraction with micro-solid-phase extraction (MSPE) using C18P-PVDF microspin filters was developed and validated for chloramphenicol (CAP) determination in honey. At validation levels of 0.10, 0.15, and 0.30 µg kg−1, apparent recoveries ranged from 102.1% to 105.1%, repeatability (RSDr) from 4.5% to 9.5%, and within-laboratory reproducibility (RSDwR) from 6.0% to 12.5%. The decision limit (CCα) was 0.123 µg kg−1, below the reference point for action of 0.15 µg kg−1, while the estimated limit of detection (LOD; not experimentally verified) was 0.01 µg kg−1.. Matrix-effect assessment across 20 honey samples showed responses within the 80–120% range for the proposed procedure and the SPE and QuEChERS comparators. No CAP was detected in the authentic honey samples. The developed workflow provides a practical, validated alternative for routine CAP determination in honey.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemical Research of Food and Feed, National Veterinary Research Institute, 24-100 Pulawy, Poland"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Tomasz Śniegocki",
      "orcid": "0000-0003-3564-3279"
    },
    {
      "affs": [
        0
      ],
      "name": "Elżbieta Samorek",
      "orcid": "0009-0000-5895-0613"
    },
    {
      "affs": [
        0
      ],
      "name": "Weronika Krajewska",
      "orcid": "0009-0009-2310-8915"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2z4tbddnk4xsj.bib",
  "cited_by": 0,
  "doi": "10.3390/molecules31213971",
  "fulltext_url": null,
  "id": "2z4tbddnk4xsj",
  "issns": [
    "1420-3049"
  ],
  "landing_url": "https://www.mdpi.com/1420-3049/31/21/3971",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-04",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/2z4tbddnk4xsj.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:21:07Z",
      "native_id": "10.3390/molecules31213971",
      "source": "crossref",
      "url": "https://www.mdpi.com/1420-3049/31/21/3971"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "issn:1420-3049",
      "subfield": "general"
    }
  ],
  "title": "Hybrid QuEChERS–Micro-Solid Phase Extraction for the Determination of Chloramphenicol in Honey by HPLC-MS/MS: Method Validation and Matrix-Effect Assessment",
  "title_text": "Hybrid QuEChERS–Micro-Solid Phase Extraction for the Determination of Chloramphenicol in Honey by HPLC-MS/MS: Method Validation and Matrix-Effect Assessment",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T00:21:09Z",
  "url": "https://research.draconitic.com/paper/2z4tbddnk4xsj",
  "venue": "Molecules",
  "versions": []
}