{
  "abstract": "Despite significant advances in nanovaccine development, their efficacy remains hindered by poor antigen presentation, limited antigen repertoire, and suboptimal T cell priming. Immune adjuvants such as polyinosinic‐polycytidylic acid (POLY(I:C)) exert antitumor effects by promoting dendritic cell (DC) maturation and stimulating innate immunity, but their efficacy is limited by poor antigen presenting cell (APC) uptake and weak CD8+ T cell responses. Here, we propose a novel adjuvant strategy using nitric oxide (NO), a bioactive gaseous molecule, to upregulate MHC‐I and enhance DC cross‐presentation, thereby synergistically improving the adjuvant efficacy of POLY(I:C). We developed a nanovaccine, Im@NOnanoPL, by co‐encapsulating a preassembled complex of DOTAP, NOC‐18, and POLY(I:C) into a PLGA shell, which was further modified with DSPE‐PEG2000 and camouflaged with immunogenic cell death (ICD)–derived tumor membranes for broad‐spectrum tumor antigen coverage. Im@NOnanoPL elicited robust and durable CD8+ T cell responses, conferring near‐complete prophylactic protection and, in combination with αPD‐1 therapy, eradicating established tumors while inducing long‐term immune memory. Im@NOnanoPL constitutes a novel vaccine platform that integrates a gas‐based adjuvant with broad‐spectrum antigens, exhibiting strong translational potential.",
  "abstract_shown": true,
  "affiliations": [
    "Peking University Third Hospital",
    "Capital Medical University",
    "The First Affiliated Hospital of China Medical University",
    "Agency For Science, Technology and Research"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Shuyu Xu"
    },
    {
      "affs": [
        1
      ],
      "name": "Yang Song"
    },
    {
      "affs": [
        0
      ],
      "name": "Tianjiao Zhang"
    },
    {
      "affs": [
        2
      ],
      "name": "Yan Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Mengxin Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Xinxin Xie"
    },
    {
      "affs": [
        3
      ],
      "name": "Qingfeng Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaolong Liang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2zkq3f381jahr.bib",
  "cited_by": 0,
  "doi": "10.1002/exp2.70238",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13654190/?tool=EBI",
  "id": "2zkq3f381jahr",
  "issns": [
    "2766-8509",
    "2766-2098"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13654190",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "2403|Immunotherapy and Immune Responses"
    ]
  ],
  "openalex": "W7221479850",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13654190/pdf/?tool=EBI",
  "pmcid": "PMC13654190",
  "pmid": "42861131",
  "published": "2026-10-11",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/2zkq3f381jahr.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:29Z",
      "native_id": "PMC:PMC13654190",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13654190"
    },
    {
      "first_seen": "2026-11-03T12:23:36Z",
      "native_id": "PMC13654190",
      "source": "pmc",
      "url": "https://doi.org/10.1002/exp2.70238"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2403|Immunotherapy and Immune Responses",
      "subfield": "immunology"
    }
  ],
  "title": "A Nitric Oxide–Based STING Agonist Nanoadjuvant With ICD‐Derived Membrane Antigens Unleashes Robust Antitumor Immunity",
  "title_text": "A Nitric Oxide–Based STING Agonist Nanoadjuvant With ICD‐Derived Membrane Antigens Unleashes Robust Antitumor Immunity",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T12:21:16Z",
  "url": "https://research.draconitic.com/paper/2zkq3f381jahr",
  "venue": "Exploration (Beijing, China)",
  "versions": []
}