{
  "abstract": "Background: Esophageal cancer (ESCA) is highly prevalent globally, but the role of RNA-binding proteins (RBPs) in it remains unclear.\n\nMethods: ESCA datasets were analyzed to identify differentially expressed genes (DEGs). Candidates were derived by intersecting DEGs with RBP-related genes and validated via machine learning, expression analysis, and receiver operating characteristic (ROC) curves. Prognostic value, functional enrichment, immune microenvironment, regulatory networks, drug prediction, and Eca-109 cell validation were assessed.\n\nResults: Four biomarkers (CDC20, COL7A1, DNMT3B, UBE2T) were confirmed. Low UBE2T/DNMT3B correlated with better survival. In addition, CDC20/UBE2T were linked to DNA replication; COL7A1/DNMT3B to olfactory transduction. Immune analysis showed 15 cell types differed significantly, with most chemokines negatively correlating with biomarkers.\n\nConclusions: COL7A1, DNMT3B, and UBE2T were associated with transcription factor TET1. The four biomarkers corresponded to 79, 26, 67, and 23 targeted drugs, respectively, and all were highly expressed in Eca-109 cells, advancing insights into RBP-related mechanisms in ESCA.\n\nSupplementary Information: The online version contains supplementary material available at https://doi.org/10.1186/s41065-026-00726-2.",
  "abstract_shown": true,
  "affiliations": [
    "School of Basic Medical Sciences, Youjiang Medical University for Nationalities, Baise, Guangxi 533000 PR China",
    "School of Clinical Medicine, Youjiang Medical University for Nationalities, Baise, Guangxi 533000 PR China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jie Gao"
    },
    {
      "affs": [
        1
      ],
      "name": "Rizhu Li"
    },
    {
      "affs": [
        1
      ],
      "name": "Xiangsheng Wu"
    },
    {
      "affs": [
        0
      ],
      "name": "Xueping Feng",
      "orcid": "0000-0001-5621-5535"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2zm3ktvpqxck6.bib",
  "cited_by": 0,
  "doi": "10.1186/s41065-026-00726-2",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13733133/",
  "id": "2zm3ktvpqxck6",
  "issns": [
    "0018-0661",
    "1601-5223"
  ],
  "landing_url": "https://doi.org/10.1186/s41065-026-00726-2",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "openalex",
      "2746|Esophageal Cancer Research and Treatment"
    ]
  ],
  "openalex": "W7196970026",
  "pdf_url": null,
  "pmcid": "PMC13733133",
  "pmid": "42983525",
  "published": "2026-08-07",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/2zm3ktvpqxck6.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:22:59Z",
      "native_id": "PMC13733133",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s41065-026-00726-2"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Esophageal Cancer Research and Treatment",
      "subfield": "surgery"
    }
  ],
  "title": "Identification and validation of RNA-binding protein-associated biomarkers in esophageal cancer",
  "title_text": "Identification and validation of RNA-binding protein-associated biomarkers in esophageal cancer",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:22:59Z",
  "url": "https://research.draconitic.com/paper/2zm3ktvpqxck6",
  "venue": "Hereditas",
  "versions": []
}