{
  "abstract": "Persistent high-risk human papillomavirus (HPV) infection initiates cervical carcinogenesis, while progression and treatment resistance also involve metabolic adaptation. O-GlcNAcylation is a reversible post-translational modification (PTM) controlled by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA), with UDP-GlcNAc generated by the hexosamine biosynthetic pathway (HBP) serving as the donor substrate. This review evaluates evidence linking HPV E6/E7-associated metabolic demand, HBP flux, O-GlcNAcylation, and mitochondrial function. We distinguish observations made under untreated conditions from acute treatment responses, identify whether validated resistant models were used, and examine HPV genotype as a source of heterogeneity. Cervical cancer studies support links between O-GlcNAcylation and pathways involved in growth and survival, but no mitochondrial O-GlcNAcylation site has been causally validated in HPV-positive cervical cancer. We therefore grade evidence by model, temporal context, and causal depth and place the proposed relationships within a broader PTM network. This synthesis separates findings obtained in cervical cancer from mechanisms inferred from other systems and identifies the main gaps limiting biomarker and therapeutic development.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "Review",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "name": "Yingying Zhang"
    },
    {
      "name": "YiMei Tao"
    },
    {
      "name": "Huirong He"
    },
    {
      "name": "Ping Li"
    },
    {
      "name": "Minbin Chen"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2zp47gaxp7pv7.bib",
  "cited_by": 0,
  "doi": "10.3389/fmolb.2026.1919738",
  "fulltext_url": null,
  "id": "2zp47gaxp7pv7",
  "issns": [
    "2296-889X"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fmolb.2026.1919738",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "feed-journal",
      "biochemistry/general"
    ]
  ],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-30",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/2zp47gaxp7pv7.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:16Z",
      "native_id": "10.3389/fmolb.2026.1919738",
      "source": "feed-frontiers",
      "url": "https://www.frontiersin.org/articles/10.3389/fmolb.2026.1919738"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "journal-openalex:1312|Protein Structure and Dynamics",
      "subfield": "molecular-biology"
    }
  ],
  "title": "HPV E6/E7, O-GlcNAcylation and mitochondrial remodeling in cervical cancer: mechanistic links and translational opportunities",
  "title_text": "HPV E6/E7, O-GlcNAcylation and mitochondrial remodeling in cervical cancer: mechanistic links and translational opportunities",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T00:20:29Z",
  "url": "https://research.draconitic.com/paper/2zp47gaxp7pv7",
  "venue": "Frontiers in Molecular Biosciences",
  "versions": []
}