{
  "abstract": "Background\n\nIn the pediatric population, carbapenem-resistant Acinetobacter baumannii (CRAB) is a significant cause of hospital-acquired infections, particularly hospital-acquired urinary tract infections (HA-UTIs). There are a few studies on the molecular mechanisms of resistance to CRAB among children.Objective\n\nTo detect the prevalence of CRAB among children with HA-UTIs and to evaluate associated carbapenemase genes and clinical risk factors.Methods\n\nThis cross-sectional study included 100 children with HA-UTIs. Isolates were identified using standard microbiology techniques, and antimicrobial resistance (AMR) was detected according to the Clinical and Laboratory Standards Institute (CLSI) guidelines. Carbapenemase genes (blaOXA-23-like, blaOXA-24/40-like, blaOXA-58-like, and blaNDM) were detected by PCR. Data were statistically analyzed to assess the association between clinical factors and carbapenem resistance (CR).Results\n\nCR was identified in 73% of isolates. High rates of AMR were observed for cephalosporins and fluoroquinolones. The most prevalent gene was the blaOXA-23-like gene (60%), followed by the blaOXA-58-like (34%), the blaOXA-24/40-like (30%), and the blaNDM (15%). A significant association was observed between resistance to carbapenems and the carbapenemase genes blaOXA-23-like and blaNDM (p < 0.05). Clinical factors like ICU admission and catheterization did not show a significant association with resistance.Conclusion\n\nCarbapenem resistance among pediatric Acinetobacter baumannii UTIs is highly prevalent and primarily driven by molecular mechanisms, particularly OXA-23 and NDM carbapenemases. This underscores the significance of molecular diagnostics and infection control in pediatric healthcare settings.",
  "abstract_shown": true,
  "affiliations": [
    "Pediatrics- Faculty of Medicine, Mansoura University, Mansoura, Egypt.",
    "Clinical Pathology-Faculty of Medicine, Mansoura University, Mansoura, Egypt. may_s@mans.edu.eg.",
    "Clinical Pathology-Faculty of Medicine, Mansoura University, Mansoura, Egypt.",
    "Department of Pediatrics, Horus University Faculty of Medicine, Damietta, Egypt."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Rasha Hassan Hassan"
    },
    {
      "affs": [
        1
      ],
      "name": "Maysaa El Sayed Zaki"
    },
    {
      "affs": [
        2
      ],
      "name": "Mohamed Saleh Ismail"
    },
    {
      "affs": [
        3
      ],
      "name": "Mohamed Ahmed Noureldin"
    },
    {
      "affs": [
        0
      ],
      "name": "Nourhan Alaa El-Din Youssef"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2zqmxdr4tst28.bib",
  "cited_by": 0,
  "doi": "10.1186/s13052-026-02349-9",
  "fulltext_url": "https://europepmc.org/articles/PMC13729496",
  "id": "2zqmxdr4tst28",
  "issns": [
    "1824-7288"
  ],
  "landing_url": "https://europepmc.org/article/MED/42972474",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "openalex",
      "1313|Antibiotic Resistance in Bacteria"
    ]
  ],
  "openalex": "W7225094238",
  "pdf_url": "https://europepmc.org/articles/PMC13729496?pdf=render",
  "pmcid": "PMC13729496",
  "pmid": "42972474",
  "published": "2026-11-02",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/2zqmxdr4tst28.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T15:20:43Z",
      "native_id": "MED:42972474",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42972474"
    },
    {
      "first_seen": "2026-11-07T12:22:15Z",
      "native_id": "PMC13729496",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s13052-026-02349-9"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1313|Antibiotic Resistance in Bacteria",
      "subfield": "general"
    }
  ],
  "title": "Carbapenem resistance in pediatric Acinetobacter baumannii urinary tract infections: molecular determinants.",
  "title_text": "Carbapenem resistance in pediatric Acinetobacter baumannii urinary tract infections: molecular determinants.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:22:15Z",
  "url": "https://research.draconitic.com/paper/2zqmxdr4tst28",
  "venue": "Italian journal of pediatrics",
  "versions": []
}