{
  "abstract": "INTRODUCTIONThe utility of blood based Alzheimers disease (AD) biomarkers in predicting clinical trajectories remains uncertain.\n\nMETHODSWe assessed the diagnostic and prognostic performance of p-tau181, p-tau217, GFAP, and NfL in a large memory{square}clinic cohort (n=3,645) with comprehensive baseline clinical evaluation and annual follow{square}up for up to three decades.\n\nRESULTSP-tau217, p-tau181 and GFAP were associated with amyloid-beta (A{beta}) pathology, while all biomarkers were elevated in AD and all-cause dementia. P-tau217 significantly outperformed others in detecting A{beta} pathology and clinical AD but performed similarly to NfL and GFAP for all-cause dementia. Prognostically, p{square}tau217 demonstrated the strongest association with cognitive decline, followed by GFAP and NfL, and best predicted progression status at 5{square} and 10{square} year intervals. All biomarkers provided added prognostic value beyond demographic and genetic covariates.\n\nDISCUSSIONThese findings support plasma biomarkers for disease identification and risk stratification while underscoring the need for population{square}specific approaches.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "PUBLISHAHEADOFPRINT",
  "arxiv": null,
  "author_total": 27,
  "authors": [
    {
      "name": "Xuemei Zeng",
      "orcid": "0000-0002-6561-5079"
    },
    {
      "name": "Nicholas Heaton",
      "orcid": "0009-0000-3181-1883"
    },
    {
      "name": "Rebecca A. Deek",
      "orcid": "0000-0002-8783-4694"
    },
    {
      "name": "Michel N. Nafash",
      "orcid": "0009-0005-6953-075X"
    },
    {
      "name": "Marissa F. Farinas",
      "orcid": "0000-0002-3889-2185"
    },
    {
      "name": "Lamia T. Choity"
    },
    {
      "name": "Wasiu G. Balogun",
      "orcid": "0000-0002-1422-8562"
    },
    {
      "name": "Ruyu Shi",
      "orcid": "0009-0004-3230-2625"
    },
    {
      "name": "Margaret A. Bedison"
    },
    {
      "name": "Brian J. Lopresti"
    },
    {
      "name": "Cristy Matan",
      "orcid": "0009-0002-2796-4136"
    },
    {
      "name": "Neelesh K. Nadkarni",
      "orcid": "0000-0002-4363-1553"
    },
    {
      "name": "Alexandra Gogola",
      "orcid": "0000-0002-8798-1715"
    },
    {
      "name": "C. Elizabeth Shaaban",
      "orcid": "0000-0002-3016-1951"
    },
    {
      "name": "Howard J. Aizenstein",
      "orcid": "0000-0003-4897-6582"
    },
    {
      "name": "Dana L. Tudorascu",
      "orcid": "0000-0003-4675-3692"
    },
    {
      "name": "Tharick A. Pascoal",
      "orcid": "0000-0001-9057-8014"
    },
    {
      "name": "Victor L. Villemagne"
    },
    {
      "name": "Sarah B. Berman",
      "orcid": "0000-0002-5096-4962"
    },
    {
      "name": "Milos D. Ikonomovic"
    },
    {
      "name": "Robert A. Sweet",
      "orcid": "0000-0001-9154-9709"
    },
    {
      "name": "Julia K. Kofler"
    },
    {
      "name": "Beth E. Snitz"
    },
    {
      "name": "M. Ilyas Kamboh",
      "orcid": "0000-0002-3453-1438"
    },
    {
      "name": "Ann D. Cohen",
      "orcid": "0000-0001-7395-9624"
    },
    {
      "name": "Oscar L. Lopez"
    },
    {
      "name": "Thomas K. Karikari",
      "orcid": "0000-0003-1422-4358"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2zse816av0qwn.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.19.26365317",
  "fulltext_url": "https://www.medrxiv.org/content/10.64898/2026.10.19.26365317v1.full",
  "id": "2zse816av0qwn",
  "issns": [],
  "landing_url": "https://www.medrxiv.org/content/10.64898/2026.10.19.26365317v1",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "medrxiv",
      "neurology"
    ],
    [
      "openalex",
      "2738|Dementia and Cognitive Impairment Research"
    ]
  ],
  "openalex": "W7223157559",
  "pdf_url": "https://www.medrxiv.org/content/10.64898/2026.10.19.26365317v1.full.pdf",
  "pmcid": "PMC13738874",
  "pmid": "42996082",
  "published": "2026-10-19",
  "publisher": "Cold Spring Harbor Laboratory Preprints",
  "ris": "https://research.draconitic.com/paper/2zse816av0qwn.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:22Z",
      "native_id": "10.64898/2026.10.19.26365317",
      "source": "medrxiv",
      "url": "https://www.medrxiv.org/content/10.64898/2026.10.19.26365317v1"
    },
    {
      "first_seen": "2026-11-09T12:23:47Z",
      "native_id": "PMC13738874",
      "source": "pmc",
      "url": "https://doi.org/10.64898/2026.10.19.26365317"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "medrxiv:neurology",
      "subfield": "neurology"
    }
  ],
  "title": "Plasma biomarkers and incident clinical stage progression in the specialized memory clinic: a longitudinal study",
  "title_text": "Plasma biomarkers and incident clinical stage progression in the specialized memory clinic: a longitudinal study",
  "type": "preprint",
  "updated_at": "2026-11-09T12:23:47Z",
  "url": "https://research.draconitic.com/paper/2zse816av0qwn",
  "venue": "medRxiv",
  "versions": []
}