{
  "abstract": "Background Terazosin (TZ) is widely prescribed for hypertension and benign prostatic hyperplasia. Recent studies suggest that TZ enhances glycolysis and may protect against neurodegenerative diseases. Methods We tested the hypothesis that TZ is neuroprotective in Alzheimer’s disease (AD) in a yeast model, a mouse model, and two human datasets. Results We report four main results. First, TZ increased ATP levels in a Saccharomyces cerevisiae mutant with impaired metabolism, and reduced Amyloid-beta42 (Aβ42) aggregation. Second, in 5xFAD mice, TZ attenuated amyloid pathology and rescued cognitive impairments in spatial memory and interval timing. Third, in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database, AD patients taking glycolysis-enhancing drugs had a slower progression of both cognitive dysfunction and metabolic neuroimaging biomarkers (18 F-fluorodeoxyglucose positron emission tomography (FDG-PET)). Finally, in the Merative Marketscan dataset, patients taking glycolysis-enhancing drugs had lower risks of developing AD. Conclusion These data provide preliminary evidence that glycolysis-enhancing drugs have therapeutic potential in AD.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Neurology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, 169 Newton Road, Iowa City, IA, 52242, USA. Qiang-zhang@uiowa.edu",
    "Department of Psychiatry, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA",
    "Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA",
    "Department of Neurology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, 169 Newton Road, Iowa City, IA, 52242, USA",
    "Department of Biology, University of Iowa, Iowa City, IA, 52242, USA",
    "Duke Medical Scientist Training Program, Department of Neurobiology, Duke University, Durham, NC, 27710, USA",
    "Johns Hopkins University, Baltimore, MD, 21205, USA",
    "Department of Pathology, University of Iowa, Iowa City, IA, 52242, USA",
    "Department of Neurology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, 169 Newton Road, Iowa City, IA, 52242, USA. Nandakumar-narayanan@uiowa.edu"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 18,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Qiang Zhang",
      "orcid": "0000-0002-4746-0392"
    },
    {
      "affs": [
        1
      ],
      "name": "Jordan L. Schultz",
      "orcid": "0000-0002-0985-7268"
    },
    {
      "affs": [
        2
      ],
      "name": "Jacob E. Simmering",
      "orcid": "0000-0001-9172-0983"
    },
    {
      "affs": [
        3
      ],
      "name": "Braedon Q Kirkpatrick",
      "orcid": "0009-0003-3436-5091"
    },
    {
      "affs": [
        3
      ],
      "name": "Matthew A. Weber",
      "orcid": "0000-0003-0488-1792"
    },
    {
      "affs": [
        4
      ],
      "name": "Sydney Skuodas",
      "orcid": "0000-0002-9454-4361"
    },
    {
      "affs": [
        4
      ],
      "name": "Tara Hicks"
    },
    {
      "affs": [
        4
      ],
      "name": "Grace Pierce"
    },
    {
      "affs": [
        4
      ],
      "name": "Margaret Laughlin"
    },
    {
      "affs": [
        3
      ],
      "name": "Benu George",
      "orcid": "0009-0001-0610-3380"
    },
    {
      "affs": [
        3
      ],
      "name": "Aimee X. Bertolli",
      "orcid": "0009-0005-0595-1125"
    },
    {
      "affs": [
        5
      ],
      "name": "Travis Larson",
      "orcid": "0000-0001-7161-231X"
    },
    {
      "affs": [
        3
      ],
      "name": "Ramasamy Thangavel",
      "orcid": "0000-0001-5006-7914"
    },
    {
      "affs": [
        6
      ],
      "name": "Mayu Oya"
    },
    {
      "affs": [
        7
      ],
      "name": "David Kyle Meyerholz",
      "orcid": "0000-0003-1552-3253"
    },
    {
      "affs": [
        3
      ],
      "name": "Georgina M. Aldridge",
      "orcid": "0000-0002-8025-1189"
    },
    {
      "affs": [
        4
      ],
      "name": "Jan S. Fassler",
      "orcid": "0000-0002-8281-6024"
    },
    {
      "affs": [
        8
      ],
      "name": "Nandakumar Narayanan",
      "orcid": "0000-0002-0427-0003"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/302aef7evadyc.bib",
  "cited_by": 5,
  "doi": "10.1186/s13195-026-02135-z",
  "fulltext_url": null,
  "id": "302aef7evadyc",
  "issns": [
    "1758-9193"
  ],
  "landing_url": "https://doi.org/10.1186/s13195-026-02135-z",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2804|Alzheimer's disease research and treatments"
    ]
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  "openalex": "W7167784347",
  "pdf_url": null,
  "pmcid": "PMC11996510",
  "pmid": "40236185",
  "published": "2026-07-09",
  "publisher": "BioMed Central",
  "ris": "https://research.draconitic.com/paper/302aef7evadyc.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T13:20:56Z",
      "native_id": "W7167784347",
      "source": "openalex",
      "url": "https://doi.org/10.1186/s13195-026-02135-z"
    }
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  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2804|Alzheimer's disease research and treatments",
      "subfield": "neuroscience"
    }
  ],
  "title": "Glycolysis-enhancing α1-adrenergic antagonists have therapeutic potential in Alzheimer’s disease",
  "title_text": "Glycolysis-enhancing α1-adrenergic antagonists have therapeutic potential in Alzheimer’s disease",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T13:20:49Z",
  "url": "https://research.draconitic.com/paper/302aef7evadyc",
  "venue": "Alzheimer s Research & Therapy",
  "versions": []
}