{
  "abstract": "There is little causal evidence on factors that can protect individuals against Alzheimer’s Disease and Related Dementias (ADRD) risk. We study the causal effect of education on ADRD, exploiting a regression discontinuity generated by a compulsory schooling reform. ADRD was ascertained based on medical history, hospital records, and death registries, addressing concerns about selective sample attrition. We find that education reduces incidence of ADRD. Using molecular genetic data, we show that the reform weakened the relationship between genetics and ADRD incidence, implying genetic risk of dementia is not immutable and can be modified by social policy.",
  "abstract_shown": true,
  "affiliations": [
    "La Follette School of Public Affairs, University of Wisconsin-Madison, Madison, WI 53706",
    "Department of Population Health Sciences, University of Wisconsin-Madison, Madison, WI 53726",
    "Center for Economic and Social Research, University of Southern California, Los Angeles, CA 90089",
    "Department of Economics, University of Southern California, Los Angeles, CA 90089",
    "Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109",
    "Survey Research Center, Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI 48106"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Silvia H. Barcellos",
      "orcid": "0000-0002-0392-0908"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Leandro S. Carvalho"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Kenneth M. Langa",
      "orcid": "0000-0002-2798-1836"
    },
    {
      "affs": [
        3
      ],
      "name": "Sneha Nimmagadda",
      "orcid": "0009-0006-1581-0972"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Patrick Turley"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/314g1w51sv598.bib",
  "cited_by": 0,
  "doi": "10.1073/pnas.2529506123",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13715751/",
  "id": "314g1w51sv598",
  "issns": [
    "0027-8424",
    "1091-6490"
  ],
  "landing_url": "https://doi.org/10.1073/pnas.2529506123",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "415"
    ],
    [
      "heading",
      "Economic Sciences"
    ],
    [
      "heading",
      "Social Sciences"
    ],
    [
      "openalex",
      "2738|Dementia and Cognitive Impairment Research"
    ]
  ],
  "openalex": "W7223368450",
  "pdf_url": null,
  "pmcid": "PMC13715751",
  "pmid": "42912790",
  "published": "2026-10-23",
  "publisher": "National Academy of Sciences",
  "ris": "https://research.draconitic.com/paper/314g1w51sv598.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T12:22:57Z",
      "native_id": "PMC13715751",
      "source": "pmc",
      "url": "https://doi.org/10.1073/pnas.2529506123"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2738|Dementia and Cognitive Impairment Research",
      "subfield": "psychiatry"
    }
  ],
  "title": "Education reduces dementia incidence and mitigates genetic risk",
  "title_text": "Education reduces dementia incidence and mitigates genetic risk",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:22:57Z",
  "url": "https://research.draconitic.com/paper/314g1w51sv598",
  "venue": "Proceedings of the National Academy of Sciences of the United States of America",
  "versions": []
}