{
  "abstract": "Background We developed an endoscopic imaging technology, oxygen saturation imaging (OS imaging), to assess real-time tissue oxygenation levels. However, its clinical impact remains unclear. This prospective observational study evaluated the association between pretreatment tumor oxygen saturation (StO2) quantified by OS imaging and the outcomes of patients with head and neck squamous cell carcinoma (HNSCC) receiving radiotherapy (RT). Methods The primary endpoint was the association between pretreatment tumor StO2 and complete response rate at 8 weeks after RT completion. Secondary endpoints were the impact of StO2 on 1-year overall survival, progression-free survival, and local failure rates. Results Of 50 patients with HNSCC enrolled from 2019 to 2022, 42 who underwent RT and OS imaging are analyzed. Of those, 41 received concurrent platinum-based chemotherapy. Median pretreatment StO2 is significantly lower in tumor tissue than in normal mucosa (61% vs. 66%, respectively). Complete response rates at 8 weeks after RT are not significantly different between the hypoxia (StO2 ≤ 61%, n = 22) and non-hypoxia (StO2 > 61%, n = 20) groups (86% vs. 100%, respectively). After a median follow-up of 36 (range: 9–53) months, the hypoxia group has significantly worse 1-year overall survival (91% vs. 100%), progression-free survival (77% vs. 95%), and local failure (18% vs. 5%) rates than the non-hypoxia group. Conclusions Despite not meeting the primary endpoint, our findings suggest that pretreatment tumor StO2 is correlated with 1-year outcomes after RT, and OS imaging may be useful for identifying RT-resistant hypoxic tumors in HNSCC.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Radiation Oncology, National Cancer Center Hospital East",
    "Department of Gastroenterology and Endoscopy, National Cancer Center Hospital East",
    "Division of Endoscopy, Saitama Cancer Center",
    "Department of Head and Neck Surgery, National Cancer Center Hospital East",
    "Department of Head and Neck Medical Oncology, National Cancer Center Hospital East",
    "Endoscopy Division, National Cancer Center Hospital",
    "Department of Radiation Oncology, National Cancer Center Hospital",
    "Division of Pathology, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 21,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Kento Tomizawa"
    },
    {
      "affs": [
        0
      ],
      "name": "Atsushi Motegi"
    },
    {
      "affs": [
        0
      ],
      "name": "Hidenari Hirata"
    },
    {
      "affs": [
        1
      ],
      "name": "Hiroki Yamashita"
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    {
      "affs": [
        1
      ],
      "name": "Hironori Sunakawa"
    },
    {
      "affs": [
        2
      ],
      "name": "Yusuke Yoda"
    },
    {
      "affs": [
        3
      ],
      "name": "Wataru Okano"
    },
    {
      "affs": [
        4
      ],
      "name": "Tomohiro Enokida"
    },
    {
      "affs": [
        0
      ],
      "name": "Takeshi Fujisawa"
    },
    {
      "affs": [
        0
      ],
      "name": "Masaki Nakamura"
    },
    {
      "affs": [
        0
      ],
      "name": "Hidehiro Hojo"
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    {
      "affs": [
        5
      ],
      "name": "Seiichiro Abe"
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    {
      "affs": [
        6
      ],
      "name": "Madoka Sakuramachi"
    },
    {
      "affs": [
        6
      ],
      "name": "Hiroshi Igaki"
    },
    {
      "affs": [
        5
      ],
      "name": "Yutaka Saito"
    },
    {
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        7
      ],
      "name": "Shingo Sakashita"
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    {
      "affs": [
        3
      ],
      "name": "Kazuto Matsuura"
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    {
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        4
      ],
      "name": "Makoto Tahara"
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    {
      "affs": [
        1
      ],
      "name": "Tomonori Yano"
    },
    {
      "affs": [
        0
      ],
      "name": "Sadamoto Zenda"
    },
    {
      "affs": [
        0
      ],
      "name": "Tetsuo Akimoto"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/317vvsb8z0h5w.bib",
  "cited_by": 0,
  "doi": "10.1038/s43856-026-01752-x",
  "fulltext_url": "https://doi.org/10.1038/s43856-026-01752-x",
  "id": "317vvsb8z0h5w",
  "issns": [
    "2730-664X"
  ],
  "landing_url": "https://doi.org/10.1038/s43856-026-01752-x",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "R"
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      "2733|Head and Neck Cancer Studies"
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  "pdf_url": "https://www.nature.com/articles/s43856-026-01752-x_reference.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-01",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/317vvsb8z0h5w.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:46:21Z",
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  "subjects": [
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  "title": "Prospective evaluation of oxygen saturation endoscopic imaging for radiotherapy response in head and neck cancer",
  "title_text": "Prospective evaluation of oxygen saturation endoscopic imaging for radiotherapy response in head and neck cancer",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:46:21Z",
  "url": "https://research.draconitic.com/paper/317vvsb8z0h5w",
  "venue": "Communications Medicine",
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