{
  "abstract": "Background: Despite major progress in HIV epidemic control, children in sub-Saharan Africa, particularly in Malawi, continue to experience poorer HIV outcomes than adults. While Malawi has made substantial progress toward the UNAIDS 95-95-95 targets, only 55% of children living with HIV are virally suppressed compared with 87% of adults. This study aims to identify and develop strategies to improve children`s access to HIV services in Malawi. Methods: Guided by the Socio-Ecological Model and the HIV care cascade framework, this multi-method study comprises four sub-studies: (1) secondary analysis of national HIV program data and spectrum estimates (2012–2023) to assess trends and progress toward the 95-95-95 targets; (2) a scoping review of health system interventions that improve paediatric HIV service access in sub-Saharan Africa (2015–2025). (3) a modified e-Delphi process with 15–30 experts to develop a context-appropriate intervention package and (4) a feasibility and acceptability assessment of the package at Kabudula Community Hospital, Lilongwe, Malawi, involving healthcare workers, community health workers, and caregivers using questionnaires and qualitative interviews. Ethical considerations: Ethical approval will be obtained from Stellenbosch University Health Research Ethics Committee (HREC) and the Malawi National Health Sciences Research Ethics Committee. Written informed consent and confidentiality will be ensured. Conclusion: This study will identify gaps in HIV care access among children, synthesize evidence on effective interventions, and develop a feasible, context-specific intervention package to strengthern children`s access to HIV services and accelerate Malawi`s progress toward achieving UNAIDS 95-95-95 targets.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Health Systems and Public Health, Department of Global Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa",
    "Department of HIV, STIs and Viral Hepatitis, Ministry of Health, Lilongwe, Malawi",
    "AFRIQUIP, Health Systems Strengthening, Johannesburg, South Africa"
  ],
  "article_type": "Study Protocol",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Bilaal Wilson Matola"
    },
    {
      "affs": [
        1
      ],
      "name": "Juliet Charity Yauka Nyasulu"
    },
    {
      "affs": [
        2
      ],
      "name": "Edward Nicol"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/31peqyv2y4s0b.bib",
  "cited_by": 0,
  "doi": "10.1371/journal.pone.0357408",
  "fulltext_url": null,
  "id": "31peqyv2y4s0b",
  "issns": [
    "1932-6203"
  ],
  "landing_url": "https://doi.org/10.1371/journal.pone.0357408",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2725|HIV/AIDS Research and Interventions"
    ],
    [
      "plos",
      "/Biology and life sciences/Immunology/Vaccination and immunization/Antiviral therapy/Antiretroviral therapy"
    ],
    [
      "plos",
      "/Biology and life sciences/Microbiology/Medical microbiology/Microbial pathogens/Viral pathogens/Immunodeficiency viruses/HIV"
    ],
    [
      "plos",
      "/Biology and life sciences/Microbiology/Medical microbiology/Microbial pathogens/Viral pathogens/Retroviruses/Lentivirus/HIV"
    ],
    [
      "plos",
      "/Biology and life sciences/Organisms/Viruses/Immunodeficiency viruses/HIV"
    ],
    [
      "plos",
      "/Biology and life sciences/Organisms/Viruses/RNA viruses/Retroviruses/Lentivirus/HIV"
    ],
    [
      "plos",
      "/Biology and life sciences/Organisms/Viruses/Viral pathogens/Immunodeficiency viruses/HIV"
    ],
    [
      "plos",
      "/Biology and life sciences/Organisms/Viruses/Viral pathogens/Retroviruses/Lentivirus/HIV"
    ],
    [
      "plos",
      "/Medicine and health sciences/Diagnostic medicine/HIV diagnosis and management"
    ],
    [
      "plos",
      "/Medicine and health sciences/Epidemiology/HIV epidemiology"
    ],
    [
      "plos",
      "/Medicine and health sciences/Health care/Health care policy"
    ],
    [
      "plos",
      "/Medicine and health sciences/Immunology/Vaccination and immunization/Antiviral therapy/Antiretroviral therapy"
    ],
    [
      "plos",
      "/Medicine and health sciences/Pathology and laboratory medicine/Pathogens/Microbial pathogens/Viral pathogens/Immunodeficiency viruses/HIV"
    ],
    [
      "plos",
      "/Medicine and health sciences/Pathology and laboratory medicine/Pathogens/Microbial pathogens/Viral pathogens/Retroviruses/Lentivirus/HIV"
    ],
    [
      "plos",
      "/Medicine and health sciences/Pediatrics"
    ],
    [
      "plos",
      "/Medicine and health sciences/Public and occupational health/Preventive medicine/Vaccination and immunization/Antiviral therapy/Antiretroviral therapy"
    ],
    [
      "plos",
      "/People and places/Geographical locations/Africa/Malawi"
    ],
    [
      "plos",
      "/Research and analysis methods/Database and informatics methods/Database searching"
    ]
  ],
  "openalex": "W7207555457",
  "pdf_url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0357408&type=printable",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-03",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/31peqyv2y4s0b.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:02Z",
      "native_id": "10.1371/journal.pone.0357408",
      "source": "plos",
      "url": "https://doi.org/10.1371/journal.pone.0357408"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "plos:immunology",
      "subfield": "immunology"
    },
    {
      "field": "biology",
      "origin": "plos:microbiology",
      "subfield": "microbiology"
    },
    {
      "field": "medicine",
      "origin": "plos:epidemiology",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Investigating strategies to enhance access to HIV services among children in Malawi: A multifaceted research approach, study protocol",
  "title_text": "Investigating strategies to enhance access to HIV services among children in Malawi: A multifaceted research approach, study protocol",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:02Z",
  "url": "https://research.draconitic.com/paper/31peqyv2y4s0b",
  "venue": "PLOS One",
  "versions": []
}