{
  "abstract": "Endometriosis affects a substantial proportion of women of reproductive age, with 30%-50% affected by infertility. A defining pathological feature is progesterone resistance resulting from impaired progesterone receptor (PGR) signaling, yet the underlying mechanisms remain incompletely understood. Here, we define conserved shared target genes of histone deacetylase 3 (HDAC3) and PGR in the mouse uterus using integrated transcriptomic and cistromic analyses, supported by uterine-specific Hdac3 and Pgr knockout mice. Co-immunoprecipitation and proximity ligation assays indicate that HDAC3 associates with PGR, with reciprocal attenuation of their expression in Hdac3- and Pgr-deficient uteri. Multiplex immunofluorescence demonstrates colocalization of HDAC3 and PGR in endometrial epithelial and stromal cells. HDAC3 and PGR expression levels show a positive correlation in stromal cells in both controls and infertile women with endometriosis, whereas this correlation in epithelial cells is selectively preserved in a subset of infertile cases. Chromatin profiling demonstrates extensive co-occupancy of HDAC3 and PGR at regulatory regions associated with progesterone-responsive genes. Together, these findings support a model in which HDAC3 functions as a coregulator of PGR-dependent transcription in the uterus and indicate that HDAC3-PGR cooperation is a key determinant of endometrial receptivity. This work provides mechanistic insight into progesterone resistance underlying endometriosis-associated infertility.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Obstetrics, Gynecology and Women's Health University of Missouri Columbia Missouri USA.",
    "Center For Reproductive Medicine and Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School Nanjing University Nanjing China.",
    "Department of Obstetrics and Gynecology Duke University Durham North Carolina USA.",
    "Department of Obstetrics and Gynecology Wake Forest Baptist Health Winston-Salem North Carolina USA.",
    "Department of Biomedical Laboratory Science Yonsei University Mirae Campus Wonju Republic of Korea."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Sohyeon Yun"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Rong Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Soo Lim Kim"
    },
    {
      "affs": [
        0
      ],
      "name": "Loan Thi Kim Nguyen"
    },
    {
      "affs": [
        0
      ],
      "name": "Shamsun Nahar"
    },
    {
      "affs": [
        0
      ],
      "name": "Keun Cheon Kim"
    },
    {
      "affs": [
        0
      ],
      "name": "DaHye Kang"
    },
    {
      "affs": [
        0
      ],
      "name": "Eunhee M Jeong"
    },
    {
      "affs": [
        0
      ],
      "name": "Lisa Brennaman"
    },
    {
      "affs": [
        0
      ],
      "name": "Mistie P Mills"
    },
    {
      "affs": [
        2
      ],
      "name": "Steven L Young"
    },
    {
      "affs": [
        3
      ],
      "name": "Bruce A Lessey"
    },
    {
      "affs": [
        0
      ],
      "name": "Tae Hoon Kim"
    },
    {
      "affs": [
        4
      ],
      "name": "Jung-Yoon Yoo"
    },
    {
      "affs": [
        0
      ],
      "name": "Jae-Wook Jeong",
      "orcid": "0000-0002-5368-6478"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/31qkkkg1t49k9.bib",
  "cited_by": 0,
  "doi": "10.1002/mco2.71122",
  "fulltext_url": "https://europepmc.org/articles/PMC13740683",
  "id": "31qkkkg1t49k9",
  "issns": [
    "2688-2663"
  ],
  "landing_url": "https://europepmc.org/article/MED/42996627",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2743|Endometriosis Research and Treatment"
    ]
  ],
  "openalex": "W7225426642",
  "pdf_url": "https://europepmc.org/articles/PMC13740683?pdf=render",
  "pmcid": "PMC13740683",
  "pmid": "42996627",
  "published": "2026-11-05",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/31qkkkg1t49k9.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T15:20:34Z",
      "native_id": "MED:42996627",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42996627"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2743|Endometriosis Research and Treatment",
      "subfield": "reproductive-child"
    }
  ],
  "title": "Histone Deacetylase 3-Progesterone Receptor Cooperation Regulates Progesterone Responsiveness in the Uterus.",
  "title_text": "Histone Deacetylase 3-Progesterone Receptor Cooperation Regulates Progesterone Responsiveness in the Uterus.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T15:20:34Z",
  "url": "https://research.draconitic.com/paper/31qkkkg1t49k9",
  "venue": "MedComm",
  "versions": []
}