{
  "abstract": ". Here we present a comprehensive human proteomic landscape, generated by profiling more than 13,000 proteins across 2,856 samples using data-independent acquisition mass spectrometry. The dataset spans 58 major tissue types, 251 specific tissue subtypes and 25 distinct carcinomas. This resource enables the depiction of spatially resolved proteome trajectories across tissue types and physiological states, including fetal, tumour, adjacent non-tumour and healthy adult tissue, thereby providing insight into both developmental processes and oncogenic progression. Furthermore, quantitative proteomics comparisons across diverse tissue types and states facilitate the indication of organ-specific toxicity, the identification of repurposable anticancer drug candidates and the prioritization of therapeutic targets for cancers. This study establishes a quantitative resource for navigating the proteome in the human body and in common cancers.",
  "abstract_shown": true,
  "affiliations": [
    "Affiliated Hangzhou First People's Hospital, State Key Laboratory of Medical Proteomics, School of Medicine, Westlake University, Hangzhou, China",
    "Research Center for Industries of the Future, School of Life Sciences, Westlake University, Hangzhou, China",
    "Westlake Center for Intelligent Proteomics, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China",
    "Department of Anatomy, College of Basic Medical Sciences, Dalian Medical University, Dalian, China",
    "Harbin Medical University Cancer Hospital, Harbin, China",
    "Department of Gynecology, Shenzhen Qianhai Taikang Hospital, Shenzhen, China",
    "Department of Gynecology, Southern Medical University Shenzhen Hospital, Shenzhen, China",
    "Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, China",
    "Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of Basic Medical Sciences, Hainan Academy of Medical Sciences, Hainan Medical University, Haikou, China",
    "Westlake Omics (Hangzhou) Biotechnology, Hangzhou, China",
    "Department of Pathology, University of Michigan, Ann Arbor, MI, USA",
    "Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA",
    "Stanley and Judith Frankel Institute for Heart and Brain Health, University of Michigan, Ann Arbor, MI, USA",
    "Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA",
    "School of Biological Sciences, Queen's University Belfast, Belfast, UK",
    "Faculty of Science, University of Zurich, Zurich, Switzerland",
    "Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland",
    "Department of Anatomy, College of Medical Sciences, South China University of Technology, Guangdong, China",
    "Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China",
    "State Key Laboratory of Frigid Zone Cardiovascular Diseases, Laboratory of Cardiovascular Disease and Molecular Intervention, Harbin Medical University, Harbin, China",
    "Department of Critical Care Medicine, Second Affiliated Hospital, Harbin Medical University, Harbin, China",
    "Affiliated Hangzhou First People's Hospital, State Key Laboratory of Medical Proteomics, School of Medicine, Westlake University, Hangzhou, China. zhuyi@westlake.edu.cn",
    "Research Center for Industries of the Future, School of Life Sciences, Westlake University, Hangzhou, China. zhuyi@westlake.edu.cn",
    "Westlake Center for Intelligent Proteomics, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China. zhuyi@westlake.edu.cn",
    "State Key Laboratory of Frigid Zone Cardiovascular Diseases, Laboratory of Cardiovascular Disease and Molecular Intervention, Harbin Medical University, Harbin, China. yongji@hrbmu.edu.cn",
    "Department of Anatomy and Physiology of College of Basic Medical Science, Shanghai Jiao Tong University, Shanghai, China. ly316@126.com",
    "Department of Emergency and Critical Disease, Songjiang Research Institute, Shanghai Key Laboratory of Emotion and Affective Disorders, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. ly316@126.com",
    "Affiliated Hangzhou First People's Hospital, State Key Laboratory of Medical Proteomics, School of Medicine, Westlake University, Hangzhou, China. guotiannan@westlake.edu.cn",
    "Research Center for Industries of the Future, School of Life Sciences, Westlake University, Hangzhou, China. guotiannan@westlake.edu.cn",
    "Westlake Center for Intelligent Proteomics, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China. guotiannan@westlake.edu.cn"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 40,
  "authors": [
    {
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        0,
        1,
        2
      ],
      "name": "Liang Yue",
      "orcid": "0000-0001-6478-7306"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Wenhao Jiang",
      "orcid": "0009-0000-9381-9848"
    },
    {
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        0,
        1,
        2
      ],
      "name": "Sainan Li",
      "orcid": "0000-0002-4201-5724"
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    {
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        3
      ],
      "name": "Meng Luo",
      "orcid": "0000-0002-2928-8277"
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    {
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        3
      ],
      "name": "Ning Fan"
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    {
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        4
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      "name": "Xiaolu Zhan"
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    {
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        2
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      "name": "Rui Sun",
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        1,
        2
      ],
      "name": "Honghan Cheng"
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    {
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      ],
      "name": "Zhangzhi Xue"
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      "name": "Tong Liu",
      "orcid": "0000-0001-9234-1328"
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        4
      ],
      "name": "Qianhe Zhou"
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    {
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        4
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      "name": "Kexin Chen",
      "orcid": "0000-0002-1503-6044"
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    {
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        1,
        2
      ],
      "name": "Tian Lu"
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    {
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        5,
        6
      ],
      "name": "Fang Guo"
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    {
      "affs": [
        7,
        8
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      "name": "Dongwei Li",
      "orcid": "0000-0002-0504-1747"
    },
    {
      "affs": [
        9
      ],
      "name": "Weigang Ge",
      "orcid": "0000-0002-1803-4327"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Zongxiang Nie"
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    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Mengge Lyu"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Jun A"
    },
    {
      "affs": [
        0,
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        2
      ],
      "name": "Yingrui Wang",
      "orcid": "0000-0001-5532-3454"
    },
    {
      "affs": [
        9
      ],
      "name": "Ying-Dan Chen",
      "orcid": "0000-0002-5367-1794"
    },
    {
      "affs": [
        9
      ],
      "name": "Zhenhai Fu"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Nan Xiang"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Lu Li"
    },
    {
      "affs": [
        10
      ],
      "name": "Fengchao Yu",
      "orcid": "0000-0002-7695-3698"
    },
    {
      "affs": [
        10
      ],
      "name": "Guo Ci Teo",
      "orcid": "0000-0003-3212-4051"
    },
    {
      "affs": [
        10,
        11
      ],
      "name": "Alexey I. Nesvizhskii",
      "orcid": "0000-0002-2806-7819"
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    {
      "affs": [
        11,
        12
      ],
      "name": "Meng Wang",
      "orcid": "0000-0001-5672-1411"
    },
    {
      "affs": [
        13
      ],
      "name": "Michael P. Snyder",
      "orcid": "0000-0003-0784-7987"
    },
    {
      "affs": [
        14
      ],
      "name": "Ben C. Collins",
      "orcid": "0000-0003-0827-3495"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Qi Xiao"
    },
    {
      "affs": [
        15,
        16
      ],
      "name": "Ruedi H. Aebersold",
      "orcid": "0000-0002-9576-3267"
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    {
      "affs": [
        17
      ],
      "name": "Fei Xu",
      "orcid": "0000-0002-8033-6844"
    },
    {
      "affs": [
        18
      ],
      "name": "Hui Yang",
      "orcid": "0000-0002-2865-5311"
    },
    {
      "affs": [
        19
      ],
      "name": "Sijia Zhang"
    },
    {
      "affs": [
        20
      ],
      "name": "Yi Han"
    },
    {
      "affs": [
        21,
        22,
        23
      ],
      "name": "Yi Zhu",
      "orcid": "0000-0003-0429-0802"
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    {
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        24
      ],
      "name": "Yong Ji",
      "orcid": "0000-0003-2650-5747"
    },
    {
      "affs": [
        25,
        26
      ],
      "name": "Yan Li",
      "orcid": "0000-0002-0697-7838"
    },
    {
      "affs": [
        27,
        28,
        29
      ],
      "name": "Tiannan Guo",
      "orcid": "0000-0003-3869-7651"
    }
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  "bibtex": "https://research.draconitic.com/paper/31tfrcw9nvrwc.bib",
  "cited_by": 8,
  "doi": "10.1038/s41586-026-10660-y",
  "fulltext_url": null,
  "id": "31tfrcw9nvrwc",
  "issns": [
    "0028-0836",
    "1476-4687"
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  "landing_url": "https://doi.org/10.1038/s41586-026-10660-y",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
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      "1607|Advanced Proteomics Techniques and Applications"
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  "pdf_url": null,
  "pmcid": "PMC13442039",
  "pmid": "42310461",
  "published": "2026-06-17",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/31tfrcw9nvrwc.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T13:21:03Z",
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      "url": "https://doi.org/10.1038/s41586-026-10660-y"
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  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1607|Advanced Proteomics Techniques and Applications",
      "subfield": "physical"
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  "title": "Spatial distribution of the proteome in the human body and in cancers",
  "title_text": "Spatial distribution of the proteome in the human body and in cancers",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T13:20:39Z",
  "url": "https://research.draconitic.com/paper/31tfrcw9nvrwc",
  "venue": "Nature",
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