{
  "abstract": "Background Comparative studies of total parathyroidectomy (TPTX) and total parathyroidectomy with autotransplantation (TPTX + AT) have primarily emphasized biochemical control and recurrence, whereas longitudinal outpatient oral calcium requirements have been less frequently quantified. This study compared short-term biochemical outcomes and postoperative calcium supplementation burden after these two procedures for refractory secondary hyperparathyroidism (SHPT). Methods We retrospectively analyzed a nonrandomized cohort of 80 patients with refractory SHPT who underwent parathyroidectomy between January and December 2021 (TPTX, n = 40; TPTX + AT, n = 40). Biochemical markers were evaluated preoperatively and at postoperative day 3 and at postoperative months 1, 3, and 6. The practical postoperative outcome was prescribed oral calcium carbonate burden (500-mg tablets/day) at discharge and at 3 and 6 months. Acute intravenous calcium use and calcitriol supplementation were also recorded. Results Both groups achieved satisfactory short-term biochemical control without major perioperative complications. Operative time was longer in the TPTX + AT group (p = 0.015). Compared with the TPTX + AT group, the TPTX group had higher serum calcium at 3 and 6 months, lower phosphate at 1 and 3 months, and lower bone-specific alkaline phosphatase and intact parathyroid hormone at 3 and 6 months. Despite these biochemical differences, acute intravenous calcium use and outpatient oral calcium and calcitriol supplementation did not differ significantly between groups. Conclusions TPTX and TPTX + AT yielded satisfactory short-term biochemical outcomes. TPTX + AT was associated with higher postoperative intact parathyroid hormone levels, compatible with greater postoperative parathyroid activity; however, no significant between-group difference in prescribed oral calcium or calcitriol supplementation burden through 6 months was detected. Because procedure allocation was nonrandomized, thymectomy practices differed, and follow-up was limited to 6 months, these findings are descriptive and do not establish procedural superiority or long-term recurrence risk.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Surgery, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Horng-Shiuan See"
    },
    {
      "affs": [
        0
      ],
      "name": "Kian-Hwee Chong"
    },
    {
      "affs": [
        0
      ],
      "name": "Yu-Tien Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Jia-Hui Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Chieh-Wen Lai"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/320ckwssrj08k.bib",
  "cited_by": 0,
  "doi": "10.1186/s12902-026-02430-8",
  "fulltext_url": "https://doi.org/10.1186/s12902-026-02430-8",
  "id": "320ckwssrj08k",
  "issns": [
    "1472-6823"
  ],
  "landing_url": "https://doi.org/10.1186/s12902-026-02430-8",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC648-665"
    ],
    [
      "openalex",
      "2746|Thyroid and Parathyroid Surgery"
    ]
  ],
  "openalex": "W7169885180",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-01",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/320ckwssrj08k.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:46:05Z",
      "native_id": "aa99874d80bc40e1b4bbd773463f203b",
      "source": "doaj",
      "url": "https://doi.org/10.1186/s12902-026-02430-8"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Thyroid and Parathyroid Surgery",
      "subfield": "surgery"
    }
  ],
  "title": "Total parathyroidectomy versus total parathyroidectomy with autotransplantation for refractory secondary hyperparathyroidism: short-term biochemical outcomes and postoperative calcium supplementation burden",
  "title_text": "Total parathyroidectomy versus total parathyroidectomy with autotransplantation for refractory secondary hyperparathyroidism: short-term biochemical outcomes and postoperative calcium supplementation burden",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:46:05Z",
  "url": "https://research.draconitic.com/paper/320ckwssrj08k",
  "venue": "BMC Endocrine Disorders",
  "versions": []
}