{
  "abstract": "Durable HIV remission requires strategies that eliminate or permanently silence the latent reservoir that persists despite antiretroviral therapy (ART). We engineer allogeneic human primary natural killer (NK) cells expressing a truncated CD4-based chimeric antigen receptor (D1D2 CAR) targeting the conserved CD4 binding site on HIV Env. D1D2 CAR NK cells selectively kill HIV-infected primary CD4 T cells in vitro and significantly delay viral rebound following ART interruption in humanized mice infected with barcoded CCR5-tropic HIV. Barcoded HIV tracking shows reductions in the number and diversity of rebounding viral RNA lineages, together with decreased inter-organ sharing of rebound-associated proviral barcodes and integration sites. Integration site and chromatin analyses suggest that rebound-associated proviruses remaining after D1D2 CAR-NK treatment are less frequently located in genic and transcriptionally active chromatin contexts. Thus, CAR-NK cells may target reactivating HIV-infected cells during early ART interruption and shape the composition of the reservoir contributing to rebound.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "name": "Yuan Shi",
      "orcid": "0000-0002-9993-0448"
    },
    {
      "name": "Izra Abbaali"
    },
    {
      "name": "William Harvey"
    },
    {
      "name": "Matthew Kostelny"
    },
    {
      "name": "Hongying Chen"
    },
    {
      "name": "Alexander Gonzalez"
    },
    {
      "name": "Melanie Dimapasoc",
      "orcid": "0000-0003-0328-315X"
    },
    {
      "name": "Suwen Li"
    },
    {
      "name": "Amélie Montel-Hagen"
    },
    {
      "name": "Christopher S. Seet",
      "orcid": "0000-0002-4821-1400"
    },
    {
      "name": "Catherine A. Blish",
      "orcid": "0000-0001-6946-7627"
    },
    {
      "name": "Jerome A. Zack",
      "orcid": "0000-0001-5486-8495"
    },
    {
      "name": "Jocelyn T. Kim"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/321fa2ch8bjy4.bib",
  "cited_by": 0,
  "doi": "10.1038/s41467-026-79036-0",
  "fulltext_url": null,
  "id": "321fa2ch8bjy4",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://www.nature.com/articles/s41467-026-79036-0",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2406|HIV Research and Treatment"
    ]
  ],
  "openalex": "W7223982641",
  "pdf_url": "https://www.nature.com/articles/s41467-026-79036-0_reference.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-27",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/321fa2ch8bjy4.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:39Z",
      "native_id": "10.1038/s41467-026-79036-0",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s41467-026-79036-0"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2406|HIV Research and Treatment",
      "subfield": "microbiology"
    }
  ],
  "title": "NK cells engineered with a chimeric antigen receptor delay HIV rebound and reshape HIV reservoir composition",
  "title_text": "NK cells engineered with a chimeric antigen receptor delay HIV rebound and reshape HIV reservoir composition",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:39Z",
  "url": "https://research.draconitic.com/paper/321fa2ch8bjy4",
  "venue": "Nature Communications",
  "versions": []
}