{
  "abstract": "Rab GTPases control myriad molecular functions by acting as a nucleotide-dependent switch for protein-protein interactions localized in discrete subcellular regions (Zerial and McBride, 2001). Finding additional molecular roles for Rab GTPases depends on expanding the identification of their nucleotide-dependent interactions. Here we compare the interactome of Rab GTPases using a comprehensive large-scale yeast 2-hybrid approach powered by quantitative high-throughput sequencing, which was used to find interactions of the major mammalian Rab isoforms locked in a GDP or GTP conformation. These data revealed an expanded set of interactions specific for GTP-bound Rab proteins, with many known Rab effectors capable of binding a wider repertoire of Rab partners than previously appreciated. We also identified the RGS domain of SNX13 and SNX14 as a new Rab GTPase-binding domain that may bridge these ER-localized proteins with Rab5 and Rab11 endosomal compartments, respectively.",
  "abstract_shown": true,
  "affiliations": [
    "University of Iowa"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "name": "T. A. Peterson"
    },
    {
      "name": "C. Ptak"
    },
    {
      "affs": [
        0
      ],
      "name": "R. C. Piper"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/330e16fc93nhr.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.15.751902",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.15.751902v1.full",
  "id": "330e16fc93nhr",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.15.751902v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "cell biology"
    ],
    [
      "openalex",
      "1307|Cellular transport and secretion"
    ]
  ],
  "openalex": "W7213519212",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.15.751902v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-15",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/330e16fc93nhr.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:55Z",
      "native_id": "10.64898/2026.09.15.751902",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.15.751902v2"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:cell biology",
      "subfield": "cell-biology"
    }
  ],
  "title": "Survey of nucleotide-specific Rab GTPase interactions reveals multiple Rab effectors",
  "title_text": "Survey of nucleotide-specific Rab GTPase interactions reveals multiple Rab effectors",
  "type": "preprint",
  "updated_at": "2026-10-30T12:26:44Z",
  "url": "https://research.draconitic.com/paper/330e16fc93nhr",
  "venue": "bioRxiv",
  "versions": []
}