{
  "abstract": "Background/Objectives: Guidance on protein and physical activity rests on population-wide minima with little differentiation by age or disease. We examined how protein intake and resistance training relate to muscle, function and mortality across clinical populations. Methods: PRISMA-guided rapid review: Fifty-eight logged PubMed queries returned 7544 unique records for screening (the analytic corpus); Europe PMC, Semantic Scholar and ClinicalTrials.gov were tested for coverage only. Estimates were extracted by a deterministic script and adjudicated by the authors; random-effects models were fitted within strata sharing an effect measure and contrast, and randomized evidence was tabulated, not pooled. Screening was single-reviewer outside a duplicate-screened sample (889 records); risk of bias was rated in duplicate. Results: In randomized trials, added protein increased strength with resistance training (+2.01%) but not without it (+0.13%); no trial of protein with resistance training reported mortality. Meeting activity guidelines was associated with lower mortality (HR 0.76, 95% CI 0.72–0.79; k = 16; I2 = 64%; low certainty). Plant protein was associated with lower mortality (HR 0.76, 0.63–0.93; k = 4; very low certainty). After excluding studies at high risk of bias, the protein strata fell to single studies. The direction of protein–outcome associations differed between populations. Conclusions: Protein with resistance training is a plausible strategy for preserving muscle and function; effects on survival are untested, and population-specific protein ranges are provisional and hypothesis-generating.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Obstetrics and Gynecology, Faculty of Health and Sport Science, Széchenyi István University, Egyetem tér 1, 9026 Győr, Hungary",
    "Doctoral School of Regional Sciences and Business Administration, Széchenyi István University, Egyetem tér 1, 9026 Győr, Hungary",
    "Department of Obstetrics and Gynecology, Albert Szent-Györgyi Medical School, University of Szeged, Semmelweis utca 1, 6725 Szeged, Hungary"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Csilla Dézsi",
      "orcid": "0000-0001-7343-9856"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Viktor Gulyás-Oldal",
      "orcid": "0009-0005-5334-4493"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Ekaterine Paschali",
      "orcid": "0009-0002-9576-5243"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Imre Gálóczi",
      "orcid": "0009-0000-2670-4549"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Sándor Nagy",
      "orcid": "0000-0002-7054-8333"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Károly Szili",
      "orcid": "0000-0001-9803-9103"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/33ebqmtgjmbq7.bib",
  "cited_by": 0,
  "doi": "10.3390/nu18193259",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13666671/?tool=EBI",
  "id": "33ebqmtgjmbq7",
  "issns": [
    "2072-6643"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13666671",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1307|Muscle metabolism and nutrition"
    ]
  ],
  "openalex": "W7216100109",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13666671/pdf/?tool=EBI",
  "pmcid": "PMC13666671",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/33ebqmtgjmbq7.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:31Z",
      "native_id": "PMC:PMC13666671",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13666671"
    },
    {
      "first_seen": "2026-10-30T12:19:56Z",
      "native_id": "10.3390/nu18193259",
      "source": "crossref",
      "url": "https://www.mdpi.com/2072-6643/18/19/3259"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1307|Muscle metabolism and nutrition",
      "subfield": "cell-biology"
    }
  ],
  "title": "Protein Intake and Resistance Training Across Clinical Populations: A PRISMA-Guided Rapid Review of Observational and Randomized Evidence",
  "title_text": "Protein Intake and Resistance Training Across Clinical Populations: A PRISMA-Guided Rapid Review of Observational and Randomized Evidence",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:56Z",
  "url": "https://research.draconitic.com/paper/33ebqmtgjmbq7",
  "venue": "Nutrients",
  "versions": []
}