{
  "abstract": "BackgroundOvarian ischemia-reperfusion (I/R) injury induces severe tissue damage through oxidative stress and inflammation, and DNA damage. This study investigated the protective effects of short- and long-term ivermectin application against ovarian I/R injury in rats.MethodsTwenty-four female Wistar albino rats were divided into four groups: sham operation (SOG), ovarian I/R (OIR), long-term ivermectin-applied I/R (LIOIR), and short-term ivermectin-applied I/R (SIOIR). Ovarian torsion was maintained for 3 h before detorsion. Ivermectin (2 mg/kg, orally) was administered for 3 or 6 days. Ovarian malondialdehyde (MDA), total glutathione (tGSH), superoxide dismutase (SOD), and catalase (CAT) were measured. Histopathological and immunohistochemical analyses of cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), and 8-hydroxy-2′-deoxyguanosine (8-OHdG) were also performed.ResultsOIR increased MDA and reduced tGSH, SOD, and CAT. Three-day ivermectin pretreatment normalized oxidative stress marker levels to values comparable to those in the sham group, whereas six-day pretreatment provided no significant protection. Follicular degeneration was pronounced in OIR and LIOIR but markedly attenuated in SIOIR. Immunohistochemistry demonstrated preserved COX-1 expression and reduced COX-2 and 8-OHdG immunoreactivity following short-term ivermectin pretreatment.ConclusionShort-term ivermectin effectively protected ovarian tissue against experimental I/R injury by reducing oxidative stress, inflammation, and DNA damage, whereas prolonged pretreatment failed to provide comparable protection, supporting its therapeutic potential.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "Original Research",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "name": "Nesrin Yilmaz"
    },
    {
      "name": "Seval Bulut"
    },
    {
      "name": "Seyma Ilayda Paltaci"
    },
    {
      "name": "Renad Mammadov"
    },
    {
      "name": "Cengiz Sarigul"
    },
    {
      "name": "Mustafa Ozkaraca"
    },
    {
      "name": "Behzat Tebrizi"
    },
    {
      "name": "Halis Suleyman"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/33ej3r4k4qhww.bib",
  "cited_by": 0,
  "doi": "10.3389/fphar.2026.2003125",
  "fulltext_url": null,
  "id": "33ej3r4k4qhww",
  "issns": [
    "1663-9812"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fphar.2026.2003125",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "feed-journal",
      "medicine/pharmacology-toxicology"
    ]
  ],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-04",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/33ej3r4k4qhww.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T06:20:41Z",
      "native_id": "10.3389/fphar.2026.2003125",
      "source": "feed-frontiers",
      "url": "https://www.frontiersin.org/articles/10.3389/fphar.2026.2003125"
    },
    {
      "first_seen": "2026-11-04T12:21:43Z",
      "native_id": "10.3389/fphar.2026.2003125",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fphar.2026.2003125/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "feed-journal:medicine/pharmacology-toxicology",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Protective effects of ivermectin against ischemia-reperfusion-induced ovarian injury in rats",
  "title_text": "Protective effects of ivermectin against ischemia-reperfusion-induced ovarian injury in rats",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T00:21:25Z",
  "url": "https://research.draconitic.com/paper/33ej3r4k4qhww",
  "venue": "Frontiers in Pharmacology",
  "versions": []
}