{
  "abstract": "Receptor-based bioassays measure mixture activity whose relationship with human physiology requires empirical assessment. We examined plasma polycyclic aromatic hydrocarbon (PAH)-like aryl hydrocarbon receptor bioactivity in the selected cross-sectional SPES biomonitoring substudy in Campania, Italy. Out of 598 assay records, 591 had quantified PAH-CALUX results and 7 were below individual limits of quantification (LOQs). Primary models related log2 lipid-normalised benzo[a]pyrene-equivalent bioactivity to homocysteine and recorded seated systolic blood pressure (SBP), adjusting for age, sex, body mass index, current smoking, and sampling cluster fixed effects, with municipality-clustered inference. Holm correction covered the two primary tests; Benjamini–Hochberg correction covered two secondary families. Participants comprised 295 women and 296 men aged 20–50 years from 63 municipalities. Per exposure doubling, homocysteine differed by −0.12% (95% confidence interval [CI], −0.76% to 0.52%; Holm-adjusted p = 0.699) and SBP by −0.37 mmHg (95% CI, −0.80 to 0.06; Holm-adjusted p = 0.183). None of the eighteen secondary outcomes met the within-family false discovery rate threshold. Additional post hoc Akins lipid normalisation and three below-LOQ substitution analyses yielded similar interpretations. These findings describe small estimated contemporaneous associations in a selected population. Uncertainty remains concerning cumulative exposure, temporal variability, and generalisability; equivalence and environmental safety cannot be inferred.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Public Health, University of Naples “Federico II”, Via Sergio Pansini 5, 80131 Naples, Italy",
    "Department of Human Sciences and Quality of Life Promotion, San Raffaele University, 00166 Rome, Italy"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Pellegrino Cerino",
      "orcid": "0009-0009-7944-239X"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Elvira De Rosa"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Maria Triassi"
    },
    {
      "affs": [
        0
      ],
      "name": "Paolo Montuori"
    },
    {
      "affs": [
        0
      ],
      "name": "Carlo Buonerba"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/33gm26t9pkden.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms27219679",
  "fulltext_url": null,
  "id": "33gm26t9pkden",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://www.mdpi.com/1422-0067/27/21/9679",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-29",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/33gm26t9pkden.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:58Z",
      "native_id": "10.3390/ijms27219679",
      "source": "crossref",
      "url": "https://www.mdpi.com/1422-0067/27/21/9679"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "issn:1422-0067",
      "subfield": "general"
    }
  ],
  "title": "Plasma PAH-like AhR Bioactivity, Homocysteine, and Subclinical Vascular and Haematologic Phenotypes in the SPES Biomonitoring Substudy",
  "title_text": "Plasma PAH-like AhR Bioactivity, Homocysteine, and Subclinical Vascular and Haematologic Phenotypes in the SPES Biomonitoring Substudy",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T00:20:54Z",
  "url": "https://research.draconitic.com/paper/33gm26t9pkden",
  "venue": "International Journal of Molecular Sciences",
  "versions": []
}