{
  "abstract": "This study aimed to evaluate the predictive value of the systemic inflammation response index (SIRI) and neutrophil-to-lymphocyte ratio (NLR), individually and combined, for therapeutic response and survival prognosis in intrahepatic cholangiocarcinoma (ICC) patients receiving immunotherapy. We retrospectively analyzed 100 ICC patients (immunotherapy group, n=82; non-immunotherapy group, n=18) treated between March 2020 and March 2025. Relationships between inflammatory markers and short-term outcomes were assessed via correlation analysis and logistic regression. The predictive performance of the joint NLR-SIRI score was evaluated using receiver operating characteristic (ROC) curves. Overall survival (OS) was analyzed using Kaplan-Meier methods and multivariate Cox regression. Significant baseline differences between groups were observed in inflammatory markers and other clinical features (P<0.05). In the immunotherapy group, multivariate logistic regression showed that NLR was significantly associated with short-term efficacy [odds ratio (OR) =0.768, P=0.02]. The joint NLR-SIRI score outperformed individual markers in predicting short-term response [area under the curve (AUC) =0.709]. Patients with a low inflammatory burden (score 0) had a progressive disease (PD) rate of only 25.81%, whereas those with a high burden (score 1-2) had an 80.00% PD rate (P<0.001). Multivariate Cox regression confirmed that high baseline SIRI [hazard ratio (HR) =7.617, P=0.01] and high NLR (HR =3.074, P=0.03) were independent unfavorable prognostic factors for OS. Furthermore, the joint score enabled significant multilayer survival risk stratification (P=0.004). Pre-treatment SIRI and NLR independently predict long-term survival in ICC patients on immunotherapy. The joint NLR-SIRI model effectively identifies patients at high risk for early treatment failure and facilitates precise survival stratification, offering an accessible, economical tool to guide personalized clinical management.",
  "abstract_shown": true,
  "affiliations": [
    "The Eighth Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Kena Lian"
    },
    {
      "affs": [
        0
      ],
      "name": "Honggang Cao"
    },
    {
      "affs": [
        0
      ],
      "name": "Zizhuang Si"
    },
    {
      "affs": [
        0
      ],
      "name": "Jian Ma"
    },
    {
      "affs": [
        0
      ],
      "name": "Bingbing Qiao"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/33rx3ak8b4s3w.bib",
  "cited_by": 0,
  "doi": "10.21037/tcr-2026-1574",
  "fulltext_url": "https://europepmc.org/articles/PMC13743210",
  "id": "33rx3ak8b4s3w",
  "issns": [
    "2218-676X",
    "2219-6803"
  ],
  "landing_url": "https://europepmc.org/article/MED/42997701",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2730|Inflammatory Biomarkers in Disease Prognosis"
    ]
  ],
  "openalex": "W7224113766",
  "pdf_url": "https://europepmc.org/articles/PMC13743210?pdf=render",
  "pmcid": "PMC13743210",
  "pmid": "42997701",
  "published": "2026-09-28",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/33rx3ak8b4s3w.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T15:20:41Z",
      "native_id": "MED:42997701",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42997701"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Inflammatory Biomarkers in Disease Prognosis",
      "subfield": "oncology"
    }
  ],
  "title": "Joint neutrophil-to-lymphocyte ratio-systemic inflammation response index score as an independent prognostic biomarker for immunotherapy-treated intrahepatic cholangiocarcinoma.",
  "title_text": "Joint neutrophil-to-lymphocyte ratio-systemic inflammation response index score as an independent prognostic biomarker for immunotherapy-treated intrahepatic cholangiocarcinoma.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T15:20:41Z",
  "url": "https://research.draconitic.com/paper/33rx3ak8b4s3w",
  "venue": "Translational cancer research",
  "versions": []
}