{
  "abstract": "Background: N6-methyladenosine (m6A) represents a prevalent internal epitranscriptomic modification of mRNA that influences post-transcriptional gene regulation. Clinically, ischemia-reperfusion (I/R) injury contributes to tissue damage in acute kidney injury, ischemic stroke, and myocardial infarction, particularly after blood flow is restored.\n\nMethods: We searched Google Scholar, Web of Science, and PubMed for literature published through May 2026. The retrieval focused on articles detailing how m6A effector proteins—specifically writers, erasers, and readers—mediate I/R pathogenesis within hepatic, renal, cardiac, and cerebral tissues.\n\nResults: m6A-associated regulation influences RNA metabolism during I/R injury. Context-dependent changes in m6A regulators and target transcripts are linked to oxidative stress, inflammatory cascades, and specific programmed cell death pathways, including ferroptosis and pyroptosis, across various organ systems.\n\nConclusion: Profiling these organ-specific m6A molecular networks may inform future research on targeted epitranscriptomic interventions for IRI.",
  "abstract_shown": true,
  "affiliations": [
    "The First Clinical Medical College of Gansu University of Chinese Medicine, Lanzhou, Gansu, China",
    "School of Basic Medical Sciences, Gansu University of Chinese Medicine, Lanzhou, Gansu, China",
    "Department of Anesthesiology, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou, Gansu, China"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Di Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Wenjuan An"
    },
    {
      "affs": [
        0
      ],
      "name": "Xing Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuhang Han"
    },
    {
      "affs": [
        1
      ],
      "name": "Guoxin Zhang"
    },
    {
      "affs": [
        2
      ],
      "name": "Lingyun Zhang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/33wmpyr072znf.bib",
  "cited_by": 0,
  "doi": "10.7717/peerj.21875",
  "fulltext_url": "https://peerj.com/articles/21875/",
  "id": "33wmpyr072znf",
  "issns": [
    "2167-8359"
  ],
  "landing_url": "https://peerj.com/articles/21875",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "QH301-705.5"
    ],
    [
      "lcc",
      "R"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://peerj.com/articles/21875.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-06",
  "publisher": "PeerJ",
  "ris": "https://research.draconitic.com/paper/33wmpyr072znf.ris",
  "sources": [
    {
      "first_seen": "2026-11-06T12:20:45Z",
      "native_id": "10.7717/peerj.21875",
      "source": "crossref",
      "url": "https://peerj.com/articles/21875"
    },
    {
      "first_seen": "2026-11-09T14:21:26Z",
      "native_id": "0a22e600000e42a79a9c5180f48fcc14",
      "source": "doaj",
      "url": "https://doi.org/10.7717/peerj.21875"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "lcc:QH301-705.5",
      "subfield": "general"
    },
    {
      "field": "medicine",
      "origin": "lcc:R",
      "subfield": "general"
    }
  ],
  "title": "Regulatory roles and molecular mechanisms of N6-methyladenosine (m6A) modification in ischemia-reperfusion injury",
  "title_text": "Regulatory roles and molecular mechanisms of N6-methyladenosine (m6A) modification in ischemia-reperfusion injury",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T14:21:26Z",
  "url": "https://research.draconitic.com/paper/33wmpyr072znf",
  "venue": "PeerJ",
  "versions": []
}