{
  "abstract": "Background\n\nMyasthenia gravis (MG) may present with prominent oculobulbar symptoms overlapping with structural brainstem disorders, creating a diagnostic challenge when neuroimaging reveals a potentially explanatory lesion. We report generalized MG with severe bulbar involvement and a concomitant tectal lesion.Case description\n\nA 23-year-old woman with autoimmune thyroiditis presented with a 4-5-month history of ptosis, diplopia, dysarthria, nasal speech, dysphagia, proximal weakness, fatigability, and episodic dyspnea. Examination revealed fatigable bilateral ptosis, facial and masticatory weakness, severe bulbar dysfunction, bilateral tongue weakness with fasciculations, cervical weakness, and symmetric proximal limb weakness, without sensory, cerebellar, or pyramidal abnormalities. Brain magnetic resonance imaging demonstrated a small left tectal fluid-attenuated inversion recovery-hyperintense lesion without contrast enhancement or significant mass effect, initially suggesting a low-grade structural lesion. However, the extensive bilateral, fluctuating, and fatigable syndrome was discordant with this finding. Anti-acetylcholine receptor antibodies were positive (2.48 nmol/L), supporting generalized MG. Treatment with pyridostigmine, corticosteroids, intravenous immunoglobulin, and azathioprine produced progressive improvement. One year later, a respiratory infection precipitated a myasthenic crisis requiring intensive care, followed by recovery. At follow-up, she remained stable without dysphagia or dyspnea, while the tectal lesion was managed conservatively.Conclusion\n\nThis case highlights the risk of diagnostic anchoring on neuroimaging abnormalities. Careful clinicoradiological correlation, particularly recognition of anatomical discordance and fatigability, is essential before attributing a complex bulbar syndrome to a structural brainstem lesion.",
  "abstract_shown": true,
  "affiliations": [
    "Clinical Research Trainee, Department of Neurosurgery, Hospital de Especialidades, Guayaquil, Ecuador.",
    "Department of Neurosurgery, Abel Gilbert Pontón Guayaquil Hospital, Guayaquil, Ecuador."
  ],
  "article_type": "case report",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Kleber Orlando Mosquera Rodriguez"
    },
    {
      "affs": [
        0
      ],
      "name": "María de Los Ángeles Álvarez Falcón"
    },
    {
      "affs": [
        1
      ],
      "name": "Juan Carlos Moreira Holguín"
    },
    {
      "affs": [
        0
      ],
      "name": "Lina Karitza Zambrano Chang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/345gwymnqt4f2.bib",
  "cited_by": 0,
  "doi": "10.25259/sni_1186_2026",
  "fulltext_url": "https://europepmc.org/articles/PMC13726834",
  "id": "345gwymnqt4f2",
  "issns": [
    "2229-5097",
    "2152-7806"
  ],
  "landing_url": "https://europepmc.org/article/MED/42974531",
  "language": "eng",
  "licence": "CC-BY-NC-SA",
  "licence_label": "CC BY-NC-SA",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-sa/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Case Report"
    ],
    [
      "openalex",
      "2728|Myasthenia Gravis and Thymoma"
    ]
  ],
  "openalex": "W7222610438",
  "pdf_url": "https://europepmc.org/articles/PMC13726834?pdf=render",
  "pmcid": "PMC13726834",
  "pmid": "42974531",
  "published": "2026-10-16",
  "publisher": "Scientific Scholar",
  "ris": "https://research.draconitic.com/paper/345gwymnqt4f2.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T15:20:48Z",
      "native_id": "MED:42974531",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42974531"
    },
    {
      "first_seen": "2026-11-05T12:23:04Z",
      "native_id": "PMC13726834",
      "source": "pmc",
      "url": "https://doi.org/10.25259/sni_1186_2026"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2728|Myasthenia Gravis and Thymoma",
      "subfield": "neurology"
    }
  ],
  "title": "When imaging misleads: Severe bulbar myasthenia gravis with a concomitant tectal lesion: A case report.",
  "title_text": "When imaging misleads: Severe bulbar myasthenia gravis with a concomitant tectal lesion: A case report.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:22:40Z",
  "url": "https://research.draconitic.com/paper/345gwymnqt4f2",
  "venue": "Surgical neurology international",
  "versions": []
}