{
  "abstract": "Background\n\nLong non-coding RNAs (lncRNAs) function as pivotal regulators in gastric cancer (GC) pathogenesis via competitive endogenous RNA (ceRNA) networks. However, the precise role of GUSBP11 in GC progression remains inadequately characterized.Aim\n\nThis investigation aimed to delineate the biological function of GUSBP11 in GC and to ascertain whether it regulates malignant phenotypes via miR-29c-3p.Methods\n\nGUSBP11, miR-29c-3p, and THBS2 expression levels were quantified in tissues and cells using RT-qPCR. Prognostic value of GUSBP11 in GC was assessed via Kaplan-Meier curve and Cox analysis. In vitro, AGS and HGC-27 cell lines were employed for loss- and gain-function assays. Cellular viability was measured via CCK-8, while migration and invasion capacities were examined using Transwell chambers. Epithelial-mesenchymal transition (EMT) markers were detected by RT-qPCR. Mechanistic interplay was validated through dual-luciferase reporter assays and miRNA inhibitor rescue experiments.Results\n\nGUSBP11 exhibited upregulation in GC tissues and cell lines, correlating significantly with lower 5-year overall survival. Functional assays demonstrated that GUSBP11 overexpression enhanced viability, migration, and invasion, whereas its knockdown elicited the opposite phenotype. Mechanistically, GUSBP11 operated as a ceRNA by sponging miR-29c-3p, thereby relieving suppression of downstream effector THBS2. Co-transfection with a miR-29c-3p inhibitor effectively reversed the tumor-suppressive consequences of GUSBP11 silencing, restoring THBS2 expression and EMT programming.Conclusion\n\nThe GUSBP11/miR-29c-3p axis exerts a pro-oncogenic influence on GC progression. This regulation offer fresh insights into GC pathophysiology and identifies prospective biomarkers for therapeutic intervention.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Gastroenterology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.",
    "Department of Gastroenterology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.",
    "Department of Gastrointestinal Surgery, Affiliated Hospital of Jiangsu University, Zhenjiang, 212001, China.",
    "Department of Hernia and Abdominal Wall Surgery, Ganzhou Hospital-Nanfang Hospital, Southern Medical University (Ganzhou People's Hospital), Ganzhou, 341000, China.",
    "Three Branches of General Surgery, Jiujiang City Key Laboratory of Cell Therapy, Jiujiang NO.1 People's Hospital, No. 48, Talingnan Road, Jiujiang, 332000, China. riweiwangdd@163.com."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yahan Zhao"
    },
    {
      "affs": [
        1
      ],
      "name": "Chan Lv"
    },
    {
      "affs": [
        2
      ],
      "name": "Jincai Chen"
    },
    {
      "affs": [
        3
      ],
      "name": "Xiaohui Wang"
    },
    {
      "affs": [
        4
      ],
      "name": "Riwei Wang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/34km071hz424m.bib",
  "cited_by": 0,
  "doi": "10.1186/s41065-026-00719-1",
  "fulltext_url": "https://europepmc.org/articles/PMC13749797",
  "id": "34km071hz424m",
  "issns": [
    "0018-0661",
    "1601-5223"
  ],
  "landing_url": "https://europepmc.org/article/MED/43010033",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1306|Cancer-related molecular mechanisms research"
    ]
  ],
  "openalex": "W7202265349",
  "pdf_url": "https://europepmc.org/articles/PMC13749797?pdf=render",
  "pmcid": "PMC13749797",
  "pmid": "43010033",
  "published": "2026-08-12",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/34km071hz424m.ris",
  "sources": [
    {
      "first_seen": "2026-11-12T15:22:43Z",
      "native_id": "MED:43010033",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/43010033"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1306|Cancer-related molecular mechanisms research",
      "subfield": "oncology"
    }
  ],
  "title": "The GUSBP11/miR-29c-3p axis facilitates gastric cancer malignancy through ceRNA mechanism.",
  "title_text": "The GUSBP11/miR-29c-3p axis facilitates gastric cancer malignancy through ceRNA mechanism.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-13T03:20:45Z",
  "url": "https://research.draconitic.com/paper/34km071hz424m",
  "venue": "Hereditas",
  "versions": []
}