{
  "abstract": "Microglia-mediated neuroinflammation is a pathological hallmark of various neurological diseases. Altered microglial states promote disease progression and induce an inflammatory microenvironment. Therapies aimed at modulating microglial signaling demonstrate certain therapeutic effects, yet their efficacy is limited in terms of durability and may sometimes have a double-edged impact. This is presumably because disease-associated microglial dysfunction stems from its multi-layered and self-reinforcing mechanisms. Microglia replacement therapy has emerged as an approach that first depletes resident microglia and then either directly transplants microglia or induces the repopulation/engraftment of microglia in the niche. This strategy shows therapeutic effects in pre-clinical models, but the intracellular mechanisms supporting its therapeutic durability remain unclear. In this review, we present a Golgi-centered, evidence-stratified perspective, proposing that Golgi homeostasis may represent a candidate organelle-level checkpoint for post-replacement microglial state stability. As a structural and signaling hub that integrates receptor maturation, innate immune signaling, lipid handling, and secretory competence, the Golgi apparatus provides a testable framework for understanding how intracellular organization may contribute to durable microglial recalibration after replacement. Direct evidence linking microglial replacement to Golgi homeostasis remains limited, and whether Golgi recovery contributes to therapeutic durability requires future validation.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Health Management, The Third Xiangya Hospital, Central South University, Changsha, China.",
    "Postdoctoral Station of Clinical Medicine, The Third Xiangya Hospital, Central South University, Changsha, China.",
    "School of Computer Science and Engineering, Central South University, Changsha, 410083, China.",
    "Department of Neurology, The Third Xiangya Hospital, Central South University, Changsha, 410013, China.",
    "Department of Neurology, The Third Xiangya Hospital, Central South University, Changsha, 410013, China. jianghong73868@csu.edu.cn.",
    "Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China. jianghong73868@csu.edu.cn.",
    "Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, 410008, China. jianghong73868@csu.edu.cn.",
    "National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, China. jianghong73868@csu.edu.cn.",
    "Hunan International Scientific and Technological Cooperation Base of Neurodegenerative and Neurogenetic Diseases, Changsha, 410008, China. jianghong73868@csu.edu.cn.",
    "National International Collaborative Research Center for Medical Metabolomics, Central South University, Changsha, 410008, China. jianghong73868@csu.edu.cn."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Shuwen Deng"
    },
    {
      "affs": [
        2
      ],
      "name": "Rong Qiu"
    },
    {
      "affs": [
        3
      ],
      "name": "Jinze Wu"
    },
    {
      "affs": [
        4,
        5,
        6,
        7,
        8,
        9
      ],
      "name": "Hong Jiang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/34qfdb73c02g3.bib",
  "cited_by": 0,
  "doi": "10.1186/s12974-026-03996-9",
  "fulltext_url": "https://europepmc.org/articles/PMC13721513",
  "id": "34qfdb73c02g3",
  "issns": [
    "1742-2094"
  ],
  "landing_url": "https://europepmc.org/article/MED/42958291",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "2808|Neuroinflammation and Neurodegeneration Mechanisms"
    ]
  ],
  "openalex": "W7172256067",
  "pdf_url": "https://europepmc.org/articles/PMC13721513?pdf=render",
  "pmcid": "PMC13721513",
  "pmid": "42958291",
  "published": "2026-08-03",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/34qfdb73c02g3.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T00:20:47Z",
      "native_id": "MED:42958291",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42958291"
    },
    {
      "first_seen": "2026-11-03T12:22:11Z",
      "native_id": "PMC13721513",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s12974-026-03996-9"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2808|Neuroinflammation and Neurodegeneration Mechanisms",
      "subfield": "neurology"
    }
  ],
  "title": "Microglia replacement therapy for neurological diseases: a mechanistic perspective focused on the Golgi apparatus.",
  "title_text": "Microglia replacement therapy for neurological diseases: a mechanistic perspective focused on the Golgi apparatus.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:22:11Z",
  "url": "https://research.draconitic.com/paper/34qfdb73c02g3",
  "venue": "Journal of neuroinflammation",
  "versions": []
}