{
  "abstract": "Maternal immune transfer is a powerful mechanism for early-life protection from infection, yet the full repertoire of protective factors remains unknown. We discovered that maternal memory T cells are both necessary and sufficient to protect offspring from lethal respiratory infection. This antigen-specific protection operated independently of maternal antibodies and offspring T cell responses and required IL-10 produced by maternal T cells. Transfer of protective maternal T cells reduced offspring inflammatory responses and lung tissue damage without affecting viral burdens, indicating that maternal memory T cells directly suppress pathogenic innate inflammatory responses to preserve offspring health. Critically, maternal vaccination similarly protected offspring in a T cell-dependent manner. These findings reveal maternal antigen-specific T cell transfer as a complementary immunological defense mechanism to protect offspring against pathogens that escape maternal antibodies, with broad implications for maternal vaccination strategies.",
  "abstract_shown": true,
  "affiliations": [
    "Fred Hutchinson Cancer Center"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "name": "H. Toure"
    },
    {
      "name": "B. Jimena"
    },
    {
      "name": "M. E. Caban"
    },
    {
      "name": "E. E. Lederer"
    },
    {
      "name": "D. M. Rico"
    },
    {
      "name": "A. Medlin McFadden"
    },
    {
      "name": "S. Abideen"
    },
    {
      "name": "P. Kokati"
    },
    {
      "name": "W. E. Harrington"
    },
    {
      "affs": [
        0
      ],
      "name": "M. A. Koch"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/34qva464wy06r.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.30.763208",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.10.30.763208v1.full",
  "id": "34qva464wy06r",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.10.30.763208v1",
  "language": null,
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "immunology"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.10.30.763208v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-30",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/34qva464wy06r.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T00:21:40Z",
      "native_id": "10.64898/2026.10.30.763208",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.10.30.763208v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:immunology",
      "subfield": "immunology"
    }
  ],
  "title": "Inherited maternal memory T cells protect offspring from respiratory viral infection through disease tolerance",
  "title_text": "Inherited maternal memory T cells protect offspring from respiratory viral infection through disease tolerance",
  "type": "preprint",
  "updated_at": "2026-11-05T00:21:09Z",
  "url": "https://research.draconitic.com/paper/34qva464wy06r",
  "venue": "bioRxiv",
  "versions": []
}