{
  "abstract": "The C. elegans Notch receptor, GLP-1, is essential for germline proliferation and early embryonic development. While the cytosolic chaperone HSP-90 promotes GLP-1 signaling in the germline, it is unknown whether the endoplasmic reticulum-resident Hsp90, ENPL-1 (GRP94/endoplasmin), also promotes GLP-1 signaling. We used RNAi knockdown of enpl-1 in a sensitized glp-1(bn18) background to investigate potential genetic interactions. RNAi-mediated knockdown of enpl-1 did not enhance reduced GLP-1/Notch signaling, and it caused a similar degree of early larval arrest in both wildtype and glp-1(bn18) backgrounds. Thus, we did not detect a role for ENPL-1 in promoting GLP-1/Notch signaling.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Biology, John Carroll University, University Heights, OH, USA",
    "Department of Mathematics, Computer Science, and Data Science, John Carroll University, University Heights, OH, USA",
    "Department of Biology, Syracuse University, Syracuse, NY, USA"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "James L. Lissemore"
    },
    {
      "affs": [
        0
      ],
      "name": "Amanda Pancake"
    },
    {
      "affs": [
        1
      ],
      "name": "Shurong Fang"
    },
    {
      "affs": [
        2
      ],
      "name": "Eleanor M. Maine"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/34rpdp6kkc83k.bib",
  "cited_by": 0,
  "doi": "10.17912/micropub.biology.002171",
  "fulltext_url": "https://www.micropublication.org/journals/biology/micropub-biology-002171",
  "id": "34rpdp6kkc83k",
  "issns": [
    "2578-9430"
  ],
  "landing_url": "https://doi.org/10.17912/micropub.biology.002171",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "QH301-705.5"
    ],
    [
      "openalex",
      "1312|Heat shock proteins research"
    ]
  ],
  "openalex": "W7167669876",
  "pdf_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13401233/pdf/25789430-2026-micropub.biology.002171.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-01",
  "publisher": "Caltech Library",
  "ris": "https://research.draconitic.com/paper/34rpdp6kkc83k.ris",
  "sources": [
    {
      "first_seen": "2026-11-06T14:21:02Z",
      "native_id": "0db70bae63e1499ba26d4a481f4780ec",
      "source": "doaj",
      "url": "https://doi.org/10.17912/micropub.biology.002171"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Heat shock proteins research",
      "subfield": "molecular-biology"
    }
  ],
  "title": "The C. elegans endoplasmic reticulum molecular chaperone ENPL-1 does not promote GLP-1/Notch signaling",
  "title_text": "The C. elegans endoplasmic reticulum molecular chaperone ENPL-1 does not promote GLP-1/Notch signaling",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T14:20:16Z",
  "url": "https://research.draconitic.com/paper/34rpdp6kkc83k",
  "venue": "microPublication Biology",
  "versions": []
}