{
  "abstract": "Local fibroblast development and densities influence organ health and disease, although it remains unclear how tissue fibroblast topography is controlled in situ. Here we defined group 2 innate lymphoid cells (ILC2) as key regulators of fibroblast homeostasis in the pancreas. ILC2 co-localised with fibroblasts expressing the genes Pi16(+)Dpp4(+)Ly6c(+) in an interstitial niche of the exocrine pancreas, which encapsulates the organ parenchyma. ILC2 specifically regulated the expansion of Pi16(+)Dpp4(+)Ly6c(+) fibroblasts, which have progenitor capacity, while restraining differentiated intra-parenchymal Col15a1(+) fibroblasts during inflammation. These circuits reinforced fibroblast numbers after injury and set an inflammatory threshold. The ILC2 and Pi16(+)Dpp4(+)Ly6c(+) fibroblast progenitor niche expanded around tumours and controlled cancer associated fibroblast ontogeny and density. Hence, ILC2-fibroblast dialogue represents a regulatory node that locally orchestrates tissue homeostasis and pathology.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 24,
  "authors": [
    {
      "name": "Thomas Yip"
    },
    {
      "name": "Julie Stockis"
    },
    {
      "name": "Charlotte Simpson"
    },
    {
      "name": "Erika Mccartney"
    },
    {
      "name": "Shwetha Raghunathan"
    },
    {
      "name": "Martha Rangel-Sosa"
    },
    {
      "name": "Sydney Hummel"
    },
    {
      "name": "Julia Moreno-Vicente"
    },
    {
      "name": "Gianmarco Raddi"
    },
    {
      "name": "Celine Garcia"
    },
    {
      "name": "Rugile Linkute"
    },
    {
      "name": "Silvain Pinaud"
    },
    {
      "name": "Maye Cheng"
    },
    {
      "name": "Lesley Hill"
    },
    {
      "name": "T. Michael Underhill"
    },
    {
      "name": "Hans-Reimer Rodewald"
    },
    {
      "name": "Christoph Schneider"
    },
    {
      "name": "Claus Jørgensen"
    },
    {
      "name": "Andrew N.J. Mckenzie"
    },
    {
      "name": "Sophie Acton"
    },
    {
      "name": "Patrick Seale"
    },
    {
      "name": "Menna Clatworthy"
    },
    {
      "name": "Matthew Buechler"
    },
    {
      "name": "Timotheus Halim"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/3500wv6j2j474.bib",
  "cited_by": 0,
  "doi": "10.1126/science.aea5113",
  "fulltext_url": null,
  "id": "3500wv6j2j474",
  "issns": [
    "0036-8075",
    "1095-9203"
  ],
  "landing_url": "https://hal.science/hal-05793511v1",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.imm"
    ],
    [
      "hal",
      "2.sdv.imm.ii"
    ],
    [
      "openalex",
      "2403|IL-33, ST2, and ILC Pathways"
    ]
  ],
  "openalex": "W7212245030",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-02",
  "publisher": "American Association for the Advancement of Science (AAAS)",
  "ris": "https://research.draconitic.com/paper/3500wv6j2j474.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:54Z",
      "native_id": "hal-05793511",
      "source": "hal",
      "url": "https://hal.science/hal-05793511v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:1.sdv.imm",
      "subfield": "immunology"
    }
  ],
  "title": "ILC2s regulate a fibroblast progenitor niche in the pancreas",
  "title_text": "ILC2s regulate a fibroblast progenitor niche in the pancreas",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:54Z",
  "url": "https://research.draconitic.com/paper/3500wv6j2j474",
  "venue": "Science",
  "versions": []
}