{
  "abstract": "Background: Cardiovascular disease prevention requires strategies for individuals at elevated metabolic risk. Polygenic risk scores (PRS) may refine risk stratification, while wearable health devices (WHDs) may support lifestyle change through self-monitoring. FitPreV assessed the feasibility and acceptability of integrating PRS-based risk communication and WHD-supported behavioural monitoring into primary cardiovascular prevention within the Italian NHS.\n\nMethods: FitPreV (ClinicalTrials.gov NCT06911294) is a pilot RCT conducted in seven general practices in Rome. Adults aged 40–69 with metabolic syndrome and 10-year cardiovascular risk of 2.5–10% were randomized to standard counselling, WHD-supported, PRS-informed, or combined intervention. Feasibility was assessed through recruitment, retention and eCRF completeness. Acceptability, participant-reported outcomes, blood tests and clinical measurements were evaluated at 12 months.\n\nResults: Of 160 eligible individuals, 120 were enrolled (recruitment rate of 75%). Overall, 82 participants completed follow-up, resulting in a retention rate of 68.3%, while eCRF completeness exceeded 90%. PRS disclosure was well accepted: 58.5% reported no anxiety, and 70.7% stated that PRS information motivated preventive behaviours. WHD use was well tolerated, with 56.4% reporting use for ≥9 months. GP acceptability was high, with 89% considering PRS integrable into practice, although self-efficacy in using PRS remained limited. Participants reported improved lifestyle behaviours, with no significant differences across arms.\n\nConclusions: FitPreV suggests that integrating PRS-informed risk communication and WHD-supported self-monitoring into primary cardiovascular prevention is feasible and acceptable. These findings support a definitive trial and highlight the need to strengthen providers’ confidence in using innovative prevention tools.\n\nFunding: Next Generation EU, Italian Ministry of University and Research (grant no. P20229BC5H).\n\nKey messages: • Personalised cardiovascular prevention using polygenic risk scores and wearable devices can be feasibly integrated into routine primary care.\n\n• Before wider health-system adoption, a definitive trial is needed with stronger strategies to improve participant retention.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "abstract",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "name": "F L Cuoco"
    },
    {
      "name": "S A Sottile"
    },
    {
      "name": "A N Romano"
    },
    {
      "name": "M F Cuoco"
    },
    {
      "name": "L E Terenzi"
    },
    {
      "name": "T I Pasciuto"
    },
    {
      "name": "C H De Waure"
    },
    {
      "name": "S T Boccia"
    },
    {
      "name": "R O Pastorino"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/357ebnk3y289z.bib",
  "cited_by": 0,
  "doi": "10.1093/eurpub/ckag169.1111",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13697684/",
  "id": "357ebnk3y289z",
  "issns": [
    "1101-1262",
    "1464-360X"
  ],
  "landing_url": "https://doi.org/10.1093/eurpub/ckag169.1111",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "6. Poster Displays"
    ],
    [
      "heading",
      "AcademicSubjects/MED00860"
    ],
    [
      "heading",
      "AcademicSubjects/SOC01210"
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      "heading",
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    [
      "heading",
      "DB. Chronic diseases, multimorbidity and non-communicable diseases"
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    [
      "openalex",
      "2739|Health Promotion and Cardiovascular Prevention"
    ]
  ],
  "openalex": "W7223692059",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13697684/pdf/?tool=EBI",
  "pmcid": "PMC13697684",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "Oxford University Press",
  "ris": "https://research.draconitic.com/paper/357ebnk3y289z.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:42Z",
      "native_id": "PMC13697684",
      "source": "pmc",
      "url": "https://doi.org/10.1093/eurpub/ckag169.1111"
    },
    {
      "first_seen": "2026-10-30T12:21:44Z",
      "native_id": "PMC:PMC13697684",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13697684"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2739|Health Promotion and Cardiovascular Prevention",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Personalised cardiovascular prevention in primary care: feasibility results from the FitPreV trial",
  "title_text": "Personalised cardiovascular prevention in primary care: feasibility results from the FitPreV trial",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:34:41Z",
  "url": "https://research.draconitic.com/paper/357ebnk3y289z",
  "venue": "The European Journal of Public Health",
  "versions": []
}